Renal cell carcinoma metastasizing to solitary fibrous tumor of the pleura: a case report.
Renal cell carcinoma metastasizing to solitary fibrous tumor of the pleura: a case report.
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DOI：
10.1186/1752-1947-5-248
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发表时间：
2011-06-29
影响因子：
1
通讯作者：
Wei S
中科院分区：
文献类型：
--
作者：
Kragel C;Wei S
肿瘤转移到另一种恶性肿瘤是一种罕见的现象。自1902年首次描述以来，文献中报告的病例不到200例，其中肺癌转移至肾细胞癌是最常见的模式。在这里，我们报告一个孤立的肺纤维瘤作为肾细胞癌的受体。据我们所知，这是第一个报告的情况下，这样的组合和第二个案件涉及一个孤立的纤维肿瘤。一名58岁的白人男子谁制定了持续干咳到我院。影像学检查显示左肺有一个巨大的胸膜肿块。肿块的活检显示梭形细胞病变与孤立性纤维瘤一致。患者接受了13 cm肿块的手术切除。病理检查证实诊断为孤立性纤维瘤，但也显示分散的转移性肾细胞癌病灶。在此之前，原发性肾细胞癌组织诊断尚未作出，最初的放射学检查是不确定的。认识到肿瘤间转移的不寻常现象对外科病理学家来说是很重要的，特别是在评估双峰组织学的肿块病变时。这个病例也强调了仔细检查手术标本的重要性，因为微小和不寻常的发现可以指导病人的护理。
A tumor metastasizing to another malignancy is an uncommon phenomenon. Since it was first described in 1902, there have been fewer than 200 cases reported in the literature, with lung cancer metastasizing to renal cell carcinoma being the most frequently described pattern. Here we report a case of a solitary fibrous tumor of the lung acting as the recipient for a renal cell carcinoma. To our knowledge, this is the first reported case of such a combination and the second case involving a solitary fibrous tumor. A 58-year-old Caucasian man who developed a persistent dry cough presented to our hospital. Imaging studies revealed a large pleural-based mass in the left lung. A biopsy of the mass showed a spindle-cell lesion consistent with a solitary fibrous tumor. The patient underwent surgical excision of the 13 cm mass. The pathological examination confirmed the diagnosis of a solitary fibrous tumor but also demonstrated discrete foci of metastatic renal cell carcinoma. Until that point, a primary renal cell carcinoma tissue diagnosis had not been made and the initial radiological work-up was inconclusive. Awareness of the unusual phenomenon of tumor-to-tumor metastasis is important for practicing surgical pathologists, particularly in the evaluation of a mass lesion showing bimodal histology. This case also highlights the importance of careful examination of surgical specimens, as minute and unusual findings can direct patient care.