Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer.
Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer.
复制标题
DOI：
10.3390/ijms17020175
复制
发表时间：
2016-02-06
影响因子：
5.6
通讯作者：
Di Vizio D
中科院分区：
文献类型：
--
作者：
Ciardiello C;Cavallini L;Spinelli C;Yang J;Reis-Sobreiro M;de Candia P;Minciacchi VR;Di Vizio D
近年来，细胞外小泡作为导致肿瘤进展的细胞间通讯途径的媒介，以及发现新的癌症生物标记物的潜在来源，受到了极大的关注。多年来，对EVS的研究主要集中在EV的生物发生机制和货物的选择与掺入，或者从现有的体液中分离EV以发现生物标志物的方法。最近的研究强调了不同的癌症来源的EV群体的存在，具有不同的分子货物，从而指出不同的EV群体可能在癌症中发挥不同的作用，而且这不是随机发生的。然而，将癌症特异性细胞间功能归因于特定人群的EV的数据仍然有限。对各种EV类型进行更深入的功能、生化和分子表征可能会发现更具选择性的临床标志物，并显著提高我们对许多癌症类型的发病机制和疾病进展的了解。
Extracellular Vesicles (EVs) have received considerable attention in recent years, both as mediators of intercellular communication pathways that lead to tumor progression, and as potential sources for discovery of novel cancer biomarkers. For many years, research on EVs has mainly investigated either the mechanism of biogenesis and cargo selection and incorporation, or the methods of EV isolation from available body fluids for biomarker discovery. Recent studies have highlighted the existence of different populations of cancer-derived EVs, with distinct molecular cargo, thus pointing to the possibility that the various EV populations might play diverse roles in cancer and that this does not happen randomly. However, data attributing cancer specific intercellular functions to given populations of EVs are still limited. A deeper functional, biochemical and molecular characterization of the various EV classes might identify more selective clinical markers, and significantly advance our knowledge of the pathogenesis and disease progression of many cancer types.