Development of recombinant cationic polymers for gene therapy research.
Development of recombinant cationic polymers for gene therapy research.
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DOI：
10.1016/j.addr.2010.04.001
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发表时间：
2010-12-30
影响因子：
16.1
通讯作者：
Hatefi, Arash
中科院分区：
文献类型：
--
作者：
Canine, Brenda F.;Hatefi, Arash
通过重组DNA技术产生的阳离子聚合物有可能填补基因递送领域的空白。这里要讨论的重组阳离子聚合物是在大肠杆菌中合成的基于氨基酸的聚合物，其目的不仅是解决有效基因递送的主要障碍，而且提供安全性、生物降解性、靶向性和成本效益。这篇综述有助于读者更好地了解重组阳离子聚合物的演变;以及它们可以提供超过病毒和合成非病毒载体的基因递送的潜在优势。它还讨论了一些主要的挑战，必须解决在未来的研究，把重组聚合物转化为临床有效的基因传递系统。生物聚合物设计的最新进展表明，这种新兴的新型基因递送系统有可能解决一些有效，安全和具有成本效益的基因治疗的主要障碍。
Cationic polymers created through recombinant DNA technology have the potential to fill a void in the area of gene delivery. The recombinant cationic polymers to be discussed here are amino acid based polymers synthesized in E.coli with the purpose to not only address the major barriers to efficient gene delivery but offer safety, biodegradability, targetability and cost-effectiveness. This review helps the readers to get a better understanding about the evolution of recombinant cationic polymers; and the potential advantages that they could offer over viral and synthetic non-viral vectors for gene delivery. It also discusses some of the major challenges that must be addressed in future studies to turn recombinant polymers into clinically effective gene delivery systems. Recent advances with the biopolymer design suggest that this emerging new class of gene delivery systems has the potential to address some of the major barriers to efficient, safe and cost-effective gene therapy.
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DOI：
10.1073/pnas.0610673104
发表时间：
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影响因子：
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