Learning and memory in streptozotocin-induced diabetic rats in a novel spatial/object discrimination task
Learning and memory in streptozotocin-induced diabetic rats in a novel spatial/object discrimination task
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DOI：
10.1016/s0166-4328(01)00186-3
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发表时间：
2001-08-01
影响因子：
2.7
通讯作者：
Gispen, WH
中科院分区：
文献类型：
--
作者：
Popovic, M;Biessels, GJ;Gispen, WH
糖尿病与认知功能障碍有关。本研究的目的是研究认知功能的糖尿病大鼠使用“可以测试”，一种新的空间/物体的学习和记忆任务，而不使用厌恶刺激。老鼠被训练从七个罐头中选择一个奖励的罐头。轻度缺水提供了获得奖励（0.3毫升水）的动机。经过5天的基线训练，其中奖励可以通过其表面和在开阔场地中的位置来标记，动物被分为两组。一组通过静脉注射链脲佐菌素诱发糖尿病。每隔2周测试一次基线训练的保持率，持续10周。接下来，使用两个改编版本的任务，每个版本有4天的训练。奖励的罐头是一个印有彩色印刷的软饮料罐。在“简单视觉任务”中，软饮料罐被放置在六个白色罐中，而在“复杂视觉任务”中，它被放置在六个不同品牌的软饮料罐中。在糖尿病大鼠中，在各种版本的测试中，正确反应的数量低于对照组，参考和工作记忆错误的数量高于对照组。任务之间的切换和任务复杂性的增加加剧了性能缺陷，这可能反映了糖尿病大鼠无法适应行为策略的任务的要求。(C)2001 Elsevier Science B. V.保留所有权利。
Diabetes mellitus is associated with disturbances of cognitive functioning. The aim of this study was to examine cognitive functioning in diabetic rats using the 'Can test', a novel spatial/object learning and memory task, without the use of aversive stimuli. Rats were trained to select a single rewarded can from seven cans. Mild water deprivation provided the motivation to obtain the reward (0.3 mi of water). After 5 days of baseline training, in which the rewarded can was marked by its surface and position in an open field, the animals were divided into two groups. Diabetes was induced in one group, by an intravenous injection of streptozotocin. Retention of baseline training was tested at 2-weekly intervals for 10 weeks. Next, two adapted versions of the task were used, with 4 days of training in each version. The rewarded can was a soft-drink can with coloured print. In a 'simple visual task' the soft-drink can was placed among six white cans, whereas in a 'complex visual task' it was placed among six soft-drink cans from different brands with distinct prints. In diabetic rats the number of correct responses was lower and number of reference and working memory errors higher than in controls in the various Versions of the test. Switches between tasks and increases in task complexity accentuated the performance deficits, which may reflect an inability of diabetic rats to adapt behavioural strategies to the demands of the tasks. (C) 2001 Elsevier Science B.V. All rights reserved.