Pigment retinopathy in warmblood horses with equine degenerative myeloencephalopathy and equine motor neuron disease.
Pigment retinopathy in warmblood horses with equine degenerative myeloencephalopathy and equine motor neuron disease.
复制标题
患有马退行性脊髓脑病和马运动神经元病的温血马色素视网膜病。
DOI：
10.1111/vop.12417
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发表时间：
2017
影响因子：
1.6
通讯作者：
Valberg,StephanieJ
中科院分区：
文献类型：
--
作者：
Finno,CarrieJ;Kaese,HeatherJ;Miller,AndrewD;Gianino,Giuliana;Divers,Thomas;Valberg,StephanieJ
在患有马运动神经元病（EMND）的成年马中报告了由慢性α-生育酚（α-TP）缺乏引起的色素性视网膜病。在患有神经轴索营养不良/马退行性脊髓脑病（NAD/EDM）的马中尚未发现色素性视网膜病，该疾病影响遗传易感的α-TP缺乏症幼马。本报告的目的是首次描述一个α-TP缺乏温血马（WB）家族的色素性视网膜病变，临床表现为NAD/EDM或EMND。动物和程序来自一个农场的25匹WB马接受了完整的神经系统和眼科检查，并评估了血清α-TP浓度。两个最严重的共济失调的马被安乐死和尸检examinationsperformed.ResultsAlpha-TP缺乏症是广泛的在这个农场（22 25匹马）。25匹马中有11匹临床正常（年龄范围2-12岁），1匹有EMND体征（6岁），10匹有与NAD/EDM一致的共济失调体征（1-10岁），其中2匹为尸检证实的并发NAD/EDM和EMND。色素视网膜病变的特点是不同量的颗粒状暗色素在绒毡层视网膜观察到四个临床明显的NAD/EDM马（两个尸检证实并发NAD/EDM和EMND）和一匹马的EMND.ConclusionsA色素视网膜病变的临床症状可以存在于年轻的α-TP-缺乏温血马EMND的临床症状，以及那些与NAD/EDM的迹象。
ObjectiveA pigment retinopathy has been reported in adult horses with equine motor neuron disease (EMND) arising from chronic α‐tocopherol (α‐TP) deficiency. A pigment retinopathy has not been identified in horses with neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) that affects genetically susceptible young horses with α‐TP deficiency. The objective of this report is to describe, for the first time, a pigment retinopathy in a family of α‐TP‐deficient Warmbloods (WB) with clinically apparent NAD/EDM or EMND.Animals and ProceduresTwenty‐five WB horses from one farm underwent complete neurologic and ophthalmic examinations and serum α‐TP concentrations were assessed. Two of the most severely ataxic horses were euthanized and postmortem examinations performed.ResultsAlpha‐TP deficiency was widespread on this farm (22 of 25 horses). Eleven of 25 horses were clinically normal (age range 2–12 years), one had signs of EMND (6 years of age), 10 had signs of ataxia consistent with NAD/EDM (1–10 years), and two of these were postmortem confirmed concurrent NAD/EDM and EMND. A pigment retinopathy characterized by varying amounts of granular dark pigment in the tapetal retina was observed in four clinically apparent NAD/EDM horses (two postmortem confirmed concurrent NAD/EDM and EMND) and one horse with clinical signs of EMND.ConclusionsA pigment retinopathy can be present in young α‐TP‐deficient Warmblood horses with clinical signs of EMND as well as those with signs of NAD/EDM.