Salivary gland carcinoma in Denmark 1990-2005: A national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)
Salivary gland carcinoma in Denmark 1990-2005: A national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)
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DOI：
10.1016/j.oraloncology.2011.04.020
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发表时间：
2011-07-01
期刊：
影响因子：
4.8
通讯作者：
Godballe, Christian
中科院分区：
文献类型：
--
作者：
Bjorndal, Kristine;Krogdahl, Annelise;Godballe, Christian
描述丹麦唾液腺癌的发病率、部位和组织学(WHO 2005)。1990年至2005年确诊的983名患者来自三个全国性的登记。相关的临床数据是从患者的病历中回顾检索出来的。组织学翻修886例(90%)。根据组织学修订，31名患者(3%)被排除在研究之外，剩下952名患者进行流行病学分析。丹麦的平均粗发病率为1.1/10万/年。男女比例为0.97，中位年龄为62岁。腮腺是最常见的部位(52.5%)，其次是口腔小涎腺(26.3%)。最常见的组织学亚型是腺样囊性癌(25.2%)、粘液表皮样癌(16.9%)、腺癌(12.2%)和腺泡细胞癌(10.2%)。翻修过程改变了886例中121例(14%)的组织学诊断。丹麦的唾液腺癌发病率高于此前报道的水平。超过一半的涎腺癌位于腮腺，其中腺样囊性癌是最常见的亚型。涎腺癌的组织学分类是困难的，由专门的病理学专家进行评估可能是最佳诊断和治疗的关键。(C)2011爱思唯尔有限公司。保留所有权利。
To describe the incidence, site and histology (WHO 2005) of salivary gland carcinomas in Denmark. Nine hundred and eighty-three patients diagnosed from 1990 to 2005 were identified from three nation-wide registries. The associated clinical data were retrospectively retrieved from patient medical records. Histological revision was performed in 886 cases (90%). Based on histological revision, 31 patients (3%) were excluded from the study leaving 952 for epidemiological analysis. The mean crude incidence in Denmark was 1.1/100,000/year. The male vs. female ratio was 0.97 and the median age was 62 years. The parotid gland was the most common site (52.5%) followed by the minor salivary glands of the oral cavity (26.3%). The most frequent histological subtypes were adenoid cystic carcinoma (25.2%), mucoepidermoid carcinoma (16.9%), adenocarcinoma NOS (12.2%) and acinic cell carcinoma (10.2%). The revision process changed the histological diagnosis in 121 out of 886 cases (14%). The incidence of salivary gland carcinoma in Denmark is higher than previously reported. More than half of salivary gland carcinomas are located in the parotid gland with adenoid cystic carcinoma being the most frequent subtype. Histological classification of salivary gland carcinomas is difficult and evaluation by dedicated pathology specialists might be essential for optimal diagnosis and treatment. (C) 2011 Elsevier Ltd. All rights reserved.