Excitation of antidromically identified neurosecretory cells of the paraventricular nucleus by oxytocin applied iontophoretically.
Excitation of antidromically identified neurosecretory cells of the paraventricular nucleus by oxytocin applied iontophoretically.
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通过离子电渗疗法应用催产素，激发逆向识别的室旁核神经分泌细胞。
DOI：
10.1016/0014-4886(72)90190-2
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发表时间：
1972
影响因子：
5.3
通讯作者：
B. A. Cross
中科院分区：
文献类型：
--
作者：
R. L. Moss;R. Dyball;B. A. Cross
将催产素离子导入下丘脑室旁核（PV）和视上核（SO）神经元细胞膜。催产素兴奋的PV单位，可以被激活逆向刺激的神经叶，但未能激发PV神经元，不能以这种方式识别和SO核，皮质和丘脑中的细胞。加压素对PV核和SO核均无兴奋作用。静脉注射催产素并不影响PV核单位的放电率，因此很难找到这些观察结果的生理意义。然而，防止这种兴奋的需要可能在某种程度上解释了与催产素合成和运输相关的复杂的神经垂体素包装系统。
Oxytocin was applied iontophoretically to the cell membrane of neurons in the paraventricular (PV) and supraoptic (SO) nuclei of the hypothalamus. Oxytocin excited the majority of PV units which could be activated antidromically by stimulation of the neural lobe but failed to excite PV neurons which could not be identified in this way and cells in the SO nucleus, cortex, and thalamus. Vasopressin had no excitatory effects either on the PV nucleus or the SO nucleus. Intravenous injections of oxytocin did not affect the firing rates of PV nucleus units, so it is hard to find a physiological meaning for these observations. However, the need to prevent such excitation may go some way to explain the elaborate neurophysin-packaging system associated with oxytocin synthesis and transport.