SPECIFIC ANTIGEN IN SERUM OF PATIENTS WITH COLON-CARCINOMA
SPECIFIC ANTIGEN IN SERUM OF PATIENTS WITH COLON-CARCINOMA
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DOI：
10.1126/science.6163212
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
SEARS, HF
中科院分区：
文献类型：
--
作者：
KOPROWSKI, H;HERLYN, M;SEARS, HF
结肠癌患者血清对结肠癌特异性单克隆抗体的结合有抑制作用，但对其他肠道疾病患者血清及健康志愿者血清无抑制作用。在其他恶性肿瘤中，2例胃癌和2例胰腺癌患者血清也抑制了单克隆抗体的特异性结合。这些血清样本中癌胚抗原的水平与其结合抑制水平无关。这种单克隆抗体可能被证明可用于检测结直肠癌。
The binding of monoclonal antibody specific for colon carcinoma was inhibited by serum from patients with adenocarcinoma of the colon but not by serum from patients with other bowel diseases or from healthy volunteers. Of other malignancies studied, serum from 2 patients with gastric carcinoma and 2 patients with pancreatic carcinoma also inhibited the specific binding of monoclonal antibody. The levels of carcinoembryonic antigen in these serum samples were not correlated with their levels of binding inhibition. Such monoclonal antibodies may prove useful for the detection of colorectal carcinoma.