Correlation of Serum and Salivary Cytokines Level With Clinical Parameters in Metabolic Syndrome With Periodontitis
Correlation of Serum and Salivary Cytokines Level With Clinical Parameters in Metabolic Syndrome With Periodontitis
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DOI：
10.1002/jcla.21917
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发表时间：
2016-09-01
影响因子：
2.7
通讯作者：
Khattri, Sanjay
中科院分区：
文献类型：
--
作者：
Chauhan, Abhishek;Yadav, Suraj Singh;Khattri, Sanjay
背景：代谢综合征（Metabolic Syndrome，MS）和慢性口腔疾病（牙周炎[PD]）都是一种炎症状态.该研究旨在确定北印度人群中MS和/或慢性PD患者血清和唾液细胞因子水平的变化。材料与方法：本横断面研究在印度北方部分进行。根据国际糖尿病联合会（IDF）的MS标准招募相似种族的研究受试者，而慢性PD则根据包深度和临床依恋水平进行诊断。ELISA法检测细胞因子水平。所有受试者分为4组：A组（MS + PD）、B组（MS）、C组（PD）和对照组D组。结果：A、B、C组血清和唾液肿瘤坏死因子α（TNF-α）水平明显高于D组（P < 0.05）。A、B、C组血清IL-10水平均低于D组（P < 0.05），但C组与D组间差异无统计学意义。A组血清IL-10水平显著低于C组（P < 0.05）。唾液IL-10水平在任何组中均未显著改变。结论：促炎性标志物TNF-α与MS伴PD患者的临床参数相关。该研究表明，唾液TNF-α水平可用作MS和PD的替代标志物。(C)2016 Wiley Periodicals，Inc.
Background: Metabolic Syndrome (MS) and chronic oral condition (periodontitis [PD]) are state of inflammation. The study was conducted to determine alterations in serum and salivary cytokines level in MS and/or chronic PD in the North Indian population. Materials and Methods: This cross-sectional study carried out in northern part of India. The study subjects of similar ethnicity were recruited according to International Diabetes Federation (IDF) criteria for MS, while chronic PD was diagnosed on the basis of packet depth and clinical attachment level. ELISA method was employed to assess cytokine level. All subjects were divided in four groups Gr A (MS + PD), B (MS), C (PD), and a control Gr D. Results: The serum and salivary tumor necrosis factor alpha (TNF-alpha) level in Gr A, B, and C was significantly higher than Gr D (P < 0.05). Serum interleukin-10 (IL-10) level in Gr A, B, and C was lower than Gr D (P < 0.05), but this difference was not significant between Gr C and Gr D. Serum IL-10 level in Gr A was significantly lower than Gr C (P < 0.05). Salivary IL-10 level was not significantly altered in any group. Conclusions: Proinflammatory marker TNF-alpha has correlation with clinical parameters in patients of MS having PD. The study suggests level of salivary TNF-alpha may be utilized as a surrogate marker of MS and PD. (C) 2016 Wiley Periodicals, Inc.