An anxiolytic action of oxytocin is enhanced by estrogen in the mouse
An anxiolytic action of oxytocin is enhanced by estrogen in the mouse
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DOI：
10.1016/s0031-9384(96)00212-0
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发表时间：
1996-11-01
影响因子：
2.9
通讯作者：
Goldman, D
中科院分区：
文献类型：
--
作者：
McCarthy, MM;McDonald, CH;Goldman, D
催产素（OT）在促进类固醇调节的生殖和亲和行为中的既定作用导致了它在某些激素条件下可能具有抗焦虑作用的推测。NM-瑞士小鼠在两种焦虑行为测试中测试对OT的反应性，即洞板装置和高架十字迷宫。剂量反应评估表明，3 mg/kg是高架十字迷宫外周给药（IF）OT的最佳剂量。在任何剂量下，对孔板装置都没有一致的影响。在用雌二醇（E（2））预处理的卵巢切除小鼠中，外周给药OT增加了进入开放臂的次数，以及与其他组相比开放臂的时间（ANOVA; p < 0.05）。OT对未用E预处理的卵巢切除动物几乎没有影响（2）。当OT脑室内给药（ICV），有增加的入口和开放的手臂上的时间相比，女性注入精氨酸加压素（AVP）。这种增加在卵巢切除的雌性中是明显的，但在用E（2）预处理的那些中进一步增强（ANOVA; p < 0.05）。相反，与接受OT的小鼠相比，E（2）预处理和ICV AVP的组合减少了高架十字迷宫的入口数量和在开放臂上花费的时间，表明AVP的雌激素调节的焦虑作用。I-[125]-OVTA结合密度的分析表明，与OIL处理的对照组相比，E（2）处理的雌性大鼠侧隔中的结合密度显著增加（ANOVA; p < 0.05）。E（2）处理对杏仁核或下丘脑腹内侧核的I-[125]-OVTA结合密度没有影响。总之，这些数据表明，OT发挥抗焦虑作用，在循环雌激素的存在下增强。这种行为效应可能是由雌激素诱导的外侧隔OT结合密度增加介导的，可能对促进社会交往很重要。版权所有（C）1996 Elsevier Science Inc.
The established role of oxytocin (OT) in facilitation of steroid-modulated reproductive and affiliative behaviors led to the speculation that it may have anxiolytic actions under certain hormonal conditions. NM-Swiss mice were tested for responsiveness to OT in two behavioral tests of anxiety, the holeboard apparatus and elevated plus-maze. Dose-response assessment indicated that 3 mg/kg was the optimal dose for peripherally administered (IF) OT on the elevated plus-maze. There were no consistent effects at any dose on the holeboard apparatus. In ovariectomized mice pretreated with estradiol (E(2)), peripherally administered OT increased the number of entrances onto the open arms, as well as the amount of time on the open arms compared to other groups (ANOVA; p < 0.05). There was little to no effect of OT in ovariectomized animals not pretreated with E(2). When OT was administered intracerebroventricularly (ICV), there was an increase in entrances and time on the open arms compared to that of females infused with arginine vasopressin (AVP). This increase was apparent in ovariectomized females, but was further enhanced in those pretreated with E(2) (ANOVA; p < 0.05). In contrast, the combination of E(2) pretreatment and ICV AVP decreased the number of entrances and time spent on the open arms of the elevated plus-maze compared to those receiving OT, suggesting an estrogen-modulated anxiogenic action of AVP. Analyses of I-[125]-OVTA binding density indicated a significant increase in binding density in the lateral septum of E(2)-treated females compared to OIL-treated controls (ANOVA; p < 0.05). There was no effect of E(2) treatment on I-[125]-OVTA binding density in the amygdala or ventromedial nucleus of the hypothalamus. Taken together, these data indicate that OT exerts an anxiolytic action that is enhanced in the presence of circulating estrogen. This behavioral effect may be mediated by estrogen-induced increases in OT binding density in the lateral septum and may be important to the facilitation of social interactions. Copyright (C) 1996 Elsevier Science Inc.