Transplacental distribution of weak acids in mice: accumulation in compartments of high pH.
Transplacental distribution of weak acids in mice: accumulation in compartments of high pH.
复制标题
小鼠体内弱酸的经胎盘分布：在高 pH 区室中积累。
DOI：
10.1002/tera.1420430407
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Nau,H
中科院分区：
文献类型：
--
作者：
Srivastava,M;Collins,MD;ScottJr,WJ;Wittfoht,W;Nau,H
三种弱酸在妊娠第11天的小鼠体内的胎盘分布被测量。与母体血浆相比，母体、胚胎和胚外隔室中药物浓度的比率遵循一致的层次结构，即羊水⩾外腔液&胚胎&>胚胎血浆&>母体骨骼肌。这种分布模式与这些隔室中的pH值有很好的相关性，表明这些隔室之间的pH梯度是决定妊娠期间弱酸性药物处置的一个影响因素。
The transplacental distribution of three weak acids was measured in mice on gestational day 11. The ratio of drug concentration in maternal, embryonic, and extraembryonic compartments compared to maternal plasma followed a consistent hierarchy such that amniotic fluid ⩾ exocoelomic fluid > embryo > embryo plasma > maternal skeletal muscle. This distribution pattern correlates well with pH in these compartments and suggests that pH gradients between compartments are an influential factor in determining weak acid drug disposition during pregnancy.