Current Practice and the Future of Deep Brain Stimulation Therapy in Parkinson's Disease.
Current Practice and the Future of Deep Brain Stimulation Therapy in Parkinson's Disease.
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DOI：
10.1055/s-0037-1601893
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发表时间：
2017-04
影响因子：
2.7
通讯作者：
Okun MS
中科院分区：
文献类型：
--
作者：
Almeida L;Deeb W;Spears C;Opri E;Molina R;Martinez-Ramirez D;Gunduz A;Hess CW;Okun MS
脑深部电刺激（DBS）是一种有效的治疗帕金森病（PD）患者经历运动波动，耐药震颤，和/或运动障碍。目前，丘脑底核和苍白球内是两个最广泛使用的目标，与个体的优点和缺点影响患者的选择。潜在的DBS患者是使用少数现有的指南和可用的DBS文献选择的，许多中心采用跨学科团队审查个人的风险-受益概况。程控设置因机构或医生特定方案而异，旨在最大限度地提高获益并限制不良反应。在评价过程中，期望应该是现实的，并明确界定，每一个令人烦恼的症状都应该在建立风险-效益简介的背景下加以解决。目前DBS研究的重点是改善症状控制、开发新技术和提高刺激输送效率。技术以更个性化的方式提供刺激，自适应DBS方法（如闭环方法）已经出现。
Deep brain stimulation (DBS) is an effective therapy for Parkinson’s disease (PD) patients experiencing motor fluctuations, medication resistant tremor, and/or dyskinesia. Currently, the subthalamic nucleus and the globus pallidus internus are the two most widely used targets, with individual advantages and disadvantages influencing patient selection. Potential DBS patients are selected using the few existing guidelines and the available DBS literature, and many centers employ an interdisciplinary team review of the individual’s risk-benefit profile. Programmed settings vary based on institution or physician specific protocols designed to maximize benefits and limit adverse effects. Expectations should be realistic and clearly defined during the evaluation process, and each bothersome symptom should be addressed in the context of building the risk-benefit profile. Current DBS research is focused on improved symptom control, the development of newer technologies, and the improved efficiency of stimulation delivery. Techniques deliver stimulation in a more personalized way, and methods of adaptive DBS such as closed loop approaches are already on the horizon.
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影响因子：
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作者：
Bronstein JM;Tagliati M;Alterman RL;Lozano AM;Volkmann J;Stefani A;Horak FB;Okun MS;Foote KD;Krack P;Pahwa R;Henderson JM;Hariz MI;Bakay RA;Rezai A;Marks WJ Jr;Moro E;Vitek JL;Weaver FM;Gross RE;DeLong MR
通讯作者：
DeLong MR
影响因子：
9.9
作者：
Esselink, RAJ;de Bie, RMA;Speelman, JD
通讯作者：
Speelman, JD
影响因子：
158.5
作者：
Follett, Kenneth A.;Weaver, Frances M.;Reda, Domenic J.
通讯作者：
Reda, Domenic J.
DOI：
10.1111/ner.12397
发表时间：
2016-06
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Akbar U;Raike RS;Hack N;Hess CW;Skinner J;Martinez-Ramirez D;DeJesus S;Okun MS
通讯作者：
Okun MS
影响因子：
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作者：
Farris S;Giroux M
通讯作者：
Giroux M