[Association study between TNFSF4 and coronary heart disease].
[Association study between TNFSF4 and coronary heart disease].
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DOI：
10.3724/sp.j.1005.2011.00239
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发表时间：
2011-03-01
期刊：
影响因子：
--
通讯作者：
Liu, Qi-Ji
中科院分区：
文献类型：
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作者：
Chen, Min-Zhi;Cheng, Guang-Hui;Liu, Qi-Ji
已有研究表明TNFSF 4是动脉粥样硬化的易感基因。但在瑞典人群和德国人群中的病例对照关联分析提供了不一致的，甚至相反的结果。为了探讨该基因与中国汉族人群冠心病的关系，我们收集了山东大学齐鲁医院498例冠心病患者和509名对照，分析了5个单核苷酸多态性（SNPs）之间的关联（rs1234314，rs45454293，rs3850641，rs1234313，和rs3861950）。在传统的基于单核苷酸多态性和单倍型的统计分析方法的基础上，引入了基于主成分得分的Logistic回归分析方法。结果表明，在Armitage趋势检验中，只有rs3861950在Bonferroni校正后具有统计学意义，其余5个SNPs均不具有统计学意义。在调整混杂因素后的Logistic回归分析中，5个SNPs均无统计学意义。单倍型分析中，6种单倍型在病例组和对照组中的频率差异有统计学意义（CTAGT（P=0.0006），CTAAC（P=0.0123），CCAGT（P=0.0004），GTGGT（P=0.0329），GCGAC（P
Previous studies suggest that TNFSF4 is a susceptibility gene of atherosclerosis. But case-control association analysis in Swedish population and German population provided inconsistent, even opposite results. In order to explore the relationship between this gene and coronary heart disease (CHD) in Chinese Han population, we collected 498 cases and 509 controls from Qilu hospital of Shandong University and analyzed the association between five single-nucleotide polymorphisms (SNPs) (rs1234314, rs45454293, rs3850641, rs1234313, and rs3861950) of TNFSF4 and CHD. On the basis of using traditional statistical analysis methods based on single SNP and haplotypes, we introduced principal component score-based logistic regression analysis to deal with the data. The results suggested that in Armitage trend test, only rs3861950 was significant, when used the Bonferroni correction, and all of the five SNPs were not statistically significant. In the logistic regression analysis which adjusts the confounding factors, all of the five SNPs were not statistically significant. In haplotype analysis, the frequencies of six haplotypes were significantly different in cases and controls (CTAGT (P=0.0006), CTAAC (P=0.0123), CCAGT (P=0.0004), GTGGT (P=0.0329), GCGAC (P