Role of the Wnt signaling pathway in bone and tooth.
Role of the Wnt signaling pathway in bone and tooth.
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DOI：
10.2741/e201
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发表时间：
2010-06
期刊：
影响因子：
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通讯作者：
M. Tamura;E. Nemoto;Mari Sato;Aiko Nakashima;H. Shimauchi
中科院分区：
文献类型：
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作者：
M. Tamura;E. Nemoto;Mari Sato;Aiko Nakashima;H. Shimauchi
Wnt信号在胚胎发育和成体体内平衡的许多过程中起着重要作用。已经鉴定了至少19种类型的Wnt、几个分泌拮抗剂家族和多种受体。两种不同的Wnt信号传导途径，经典途径和非经典途径已被描述。相关动物模型的功能研究和实验分析证实了Wnt对发育中的矿化组织形成和成体稳态的调节作用。在成骨细胞中，经典Wnt通路调节分化、增殖和矿化，同时通过增加骨保护素阻断细胞凋亡和破骨细胞生成。在成骨细胞分化过程中，Wnt和骨形态发生蛋白信号之间的功能串扰已经被报道。最近，非经典Wnt信号被证明在骨形成中发挥作用。Wnt信号通路不仅在牙齿的形成中起重要作用，而且在牙齿中的成牙骨质细胞和成牙本质细胞的分化和增殖中也起重要作用。本文综述了Wnt信号通路在骨和牙齿中的作用及其治疗潜力的研究进展。
Signaling by the Wnt plays a central role in many processes during embryonic development and adult homeostasis. At least 19 types of Wnts, several families of secreted antagonists and multiple receptors have been identified. Two distinct Wnt signaling pathways, the canonical pathway and the noncanonical pathway have been described. Functional studies and experimental analysis of relevant animal models confirmed the effects of Wnt on regulation of developing mineralized tissue formation and adult homeostasis. In osteoblasts, the canonical Wnt pathway modulates differentiation, proliferation and mineralization, while it blocks apoptosis and osteoclastogenesis by increasing osteoprotegerin. Functional crosstalk between Wnt and bone morphogenetic protein signaling during osteoblastic differentiation has been reported. Recently, non-canonical Wnt signaling was shown to play a role in bone formation. The Wnt signaling pathway also plays an important role not only in tooth formation but also in differentiation and proliferation of cementoblasts and odontoblasts in the tooth. This present review provides an overview of progress in elucidating the role of Wnt signaling pathways in bone and tooth and the resulting possibilities for therapeutic potential.