Selective degradation of peroxisomes in yeasts
Selective degradation of peroxisomes in yeasts
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DOI：
10.1002/jemt.10325
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发表时间：
2003-06-01
影响因子：
2.5
通讯作者：
Kiel, JAKW
中科院分区：
文献类型：
--
作者：
Bellu, AR;Kiel, JAKW
过氧化物酶体是真核生物的重要细胞器，在过去的二十年里，人们对过氧化物酶体的诱导和生物合成过程的研究取得了很大进展。直到最近，第一个分子研究的选择性降解这一重要的细胞器-一个过程被称为pexophagy，发生时，细胞器已成为多余的-已经执行，特别是使用甲基营养酵母。发现pexophagy和其他运输途径的液泡（液泡蛋白分选，自噬，细胞质到液泡的靶向和内吞作用）利用共同的，但也独特的基因，将pexophagy置于心脏的机器，使细胞物质。目前的研究主要集中在了解过氧化物酶体降解是如何成为一个高度选择性的过程以及触发它的信号是什么。此外，由于吞噬的主要决定因素位于过氧化物酶体本身，因此详细研究过氧化物酶体膜蛋白在降解过程中的作用变得至关重要。这一审查突出了过去几年的主要成就。(C)2003 Wiley-Liss，Inc.
In the last two decades, much progress has been made in understanding the process of induction and biogenesis of peroxisomes, essential organelles in all eukaryotes. Only relatively recently, the first molecular studies on the selective degradation of this important organelle-a process known as pexophagy, which occurs when the organelles have become redundant-have been performed, especially using methylotrophic yeasts. The finding that pexophagy and other transport pathways to the vacuole (vacuolar protein sorting, autophagy, cytoplasm-to-vacuole-targeting and endocytosis) utilize common but also unique genes has placed pexophagy in the heart of the machinery that recycles cellular material. The quest is now on to understand how peroxisome degradation has become such a highly selective process and what the signals are that trigger it. In addition, because the prime determinant of pexophagy is located on the peroxisome itself, it has become essential to study the role of peroxisomal membrane proteins in the degradation process in detail. This review highlights the main achievements of the last years. (C) 2003 Wiley-Liss, Inc.