SKELETAL-MUSCLE METABOLISM IS A MAJOR DETERMINANT OF RESTING ENERGY-EXPENDITURE
SKELETAL-MUSCLE METABOLISM IS A MAJOR DETERMINANT OF RESTING ENERGY-EXPENDITURE
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DOI：
10.1172/jci114857
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发表时间：
1990-11-01
影响因子：
15.9
通讯作者：
RAVUSSIN, E
中科院分区：
文献类型：
--
作者：
ZURLO, F;LARSON, K;RAVUSSIN, E
能量消耗因人而异，与身体大小和成分无关，代谢率“低”的人似乎有更高的体重增加风险。为了评价骨骼肌代谢作为代谢率决定因素的重要性，采用间接量热法测定了14名受试者(男7人，女7人；睡眠代谢率30人)的24小时能量消耗、基础代谢率(BMR)和睡眠代谢率(SMR)。6岁[平均值+-]Sd]；79.1+-。17.3公斤；22。+-。7%的体脂)，并与前臂摄氧量进行比较。能量消耗的值根据脱脂质量、脂肪质量、年龄和性别的个体差异进行了调整。调整后的基础代谢率和基础代谢率与前臂静息摄氧量(mLO2/L前臂)呈正相关(r=0.005.72，P<0.0 5)，与预测值的偏差表示。这些发现表明，静息肌肉代谢的差异是个体代谢率差异的部分原因，并可能在肥胖的发病机制中发挥作用。
Energy expenditure varies among people, independent of body size and composition, and persons with a "low" metabolic rate seem to be at higher risk of gaining weight. To assess the importance of skeletal muscle metabolism as a determinant of metabolic rate, 24-h energy expenditure, basal metabolic rate (BMR), and sleeping metabolic rate (SMR) were measured by indirect calorimetry in 14 subjects (7 males, 7 females; 30 .+-. 6 yr [mean .+-. SD]; 79.1 .+-. 17.3 kg; 22 .+-. 7% body fat), and compared to forearm oxygen uptake. Values of energy expenditure were adjusted for individual differences in fat-free mass, fat mass, age, and sex. Adjusted BMR and SMR, expressed as deviations from predicted values, correlated with forearm resting oxygen uptake (ml O2/liter forearm) (r = 0.72, P < 0.005 and r = 0.53, P = 0.05, respectively). These findings suggest that differences in resting muscle metabolism account for part of the variance in metabolic rate among individuals and may play a role in the pathogenesis of obesity.