B vitamin status and inflammatory markers
B vitamin status and inflammatory markers
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DOI：
10.1016/s0021-9150(03)00161-8
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发表时间：
2003-07-01
期刊：
影响因子：
5.3
通讯作者：
Chambless, LE
中科院分区：
文献类型：
--
作者：
Folsom, AR;Desvarieux, M;Chambless, LE
有限的证据表明，循环中低水平的吡哆醛-5‘-磷酸(PLP)可能与炎症标志物C-反应蛋白(CRP)的升高有关。我们试图确定已报道的CRP与PLP的相关性是否具有特异性，而对于其他炎症或止血标志物是否具有普遍性。在社区动脉粥样硬化风险(ARIC)研究的519名健康中年人中，我们分析了同型半胱氨酸、血浆和膳食B维生素水平与炎症、内皮功能障碍或血栓形成相关的多个标记物的横断面关系：C反应蛋白、纤维蛋白原、白细胞计数、细胞内黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)、E-选择素、第八因子和血管性血友病因子。Von Willebrand因子、I-CAM或V-CAM与所检测的任何血浆或饮食指标均无显著关联(P>；0.05)，也没有与血清同型半胱氨酸显著相关的标志物。与我们的假设相反，血浆PLP与CRP浓度无关。较高的白细胞计数与较低的B族维生素状况(较低的血浆PLP和叶酸，较低的饮食B6和B12)相关，但与维生素补充剂的使用无关。在表面上健康的成年人身上。维生素B的状态与循环中炎症标志物和细胞黏附分子的水平没有很强的相关性。或血栓形成因子。(C)2003爱思唯尔爱尔兰科学有限公司。保留所有权利。
Limited evidence has suggested that low levels of circulating pyridoxal-5'-phosphate (PLP) may be associated with elevation of the inflammatory marker, C-reactive protein (CRP). We sought to determine whether the reported association of CRP with PLP was specific versus generalizable to other inflammation or hemostasis markers. Among 519 healthy middle aged adults in the Atherosclerosis Risk in Communities (ARIC) Study, we analyzed the cross-sectional relation of homocysteine, plasma and dietary B vitamin levels with multiple markers implicated in inflammation, endothelial dysfunction, or thrombogenesis: CRP, fibrinogen, white blood cell count, intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, factor VIII, and von Willebrand factor. There was no significant association (P > 0.05) of von Willebrand factor, I-CAM, or V-CAM with any of the plasma or dietary measures examined, and no marker was associated significantly with serum homocysteine. Contrary to our hypothesis, plasma PLP was not associated with CRP concentration. A higher white blood cell count was associated with lower B vitamin status (lower plasma PLP and folate, lower dietary B6 and B12), though not with use of vitamin supplements. In ostensibly healthy adults. B-vitamin status is not a strong correlate of circulating levels of inflammatory markers, cellular adhesion molecules. or thrombogenic factors. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.