Yeast, a model organism for iron and copper metabolism studies
Yeast, a model organism for iron and copper metabolism studies
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DOI：
10.1023/a:1020771000746
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发表时间：
2003-03-01
期刊：
影响因子：
3.5
通讯作者：
Vulpe, C
中科院分区：
文献类型：
--
作者：
De Freitas, J;Wintz, H;Vulpe, C
地球上几乎所有的生物都依赖于过渡金属来生存。铁和铜特别重要，因为它们参与重要的电子转移反应，因此是许多代谢酶的辅因子。它们转移电子的能力也使它们在过量存在时具有毒性。铁和铜稳态水平的紊乱可能对细胞代谢、生长和发育产生深远影响。将这些金属保持在实用性和毒性之间的狭窄范围内至关重要。从细菌、植物到哺乳动物，生物体都已经发展出复杂的机制来控制金属的体内平衡。在本文中，我们将概述目前对酵母中铁和铜代谢的了解，以及酵母作为研究哺乳动物和植物铁和铜代谢的模式生物的实用性。
Virtually all organisms on earth depend on transition metals for survival. Iron and copper are particularly important because they participate in vital electron transfer reactions, and are thus cofactors of many metabolic enzymes. Their ability to transfer electrons also render them toxic when present in excess. Disturbances of iron and copper steady-state levels can have profound effects on cellular metabolism, growth and development. It is critical to maintain these metals in a narrow range between utility and toxicity. Organisms ranging from bacteria and plants to mammals have developed sophisticated mechanisms to control metal homeostasis. In this review, we will present an overview of the current understanding of iron and copper metabolism in yeast, and the utility of yeast as a model organism to investigate iron and copper metabolism in mammals and plants.