Persistent infection, inflammation, and functional impairment in older Latinos
Persistent infection, inflammation, and functional impairment in older Latinos
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DOI：
10.1093/gerona/63.6.610
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发表时间：
2008-06-01
影响因子：
5.1
通讯作者：
Liang, Jersey
中科院分区：
文献类型：
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作者：
Aiello, Allison E.;Haan, Mary N.;Liang, Jersey
背景本研究的目的是检查是否巨细胞病毒（CMV），单纯疱疹病毒1型（HSV-1），C-反应蛋白（CRP）与老年拉丁美洲人的功能障碍。对社区老年人群进行了队列研究的横断面分析。样本是萨克拉门托地区拉丁裔老龄化研究（SALSA）中年龄60-101岁的受试者的子集（N= 1559/1789），具有可用的血清样本和功能障碍测量。测定基线血清样本的CMV和HSV-1免疫球蛋白G抗体水平以及CRP水平。采用日常生活活动能力（ADL）、工具性日常生活活动能力（IADL）和步行速度等指标评估功能障碍。即使在控制了年龄和性别后，CMV和CRP与ADL功能障碍也显示出统计学显著的分级相关性。CMV和ADL之间的关系略有减弱，当调整健康状况总数，体重指数和家庭收入时，置信区间包含零值。即使调整了所有其他协变量后，只有高水平的CRP与ADL和IADL受损显著相关。炎症显然与老年拉丁美洲人的身体功能有关。这项研究还表明CMV感染与ADL障碍有关。进一步研究感染，免疫反应和炎症对身体功能纵向轨迹的影响是必要的。
Background. The objective of this study was to examine whether cytomegalovirus (CMV), herpes simplex virus type-1 (HSV-1), and C-reactive protein (CRP) are associated with functional impairment in older Latinos.Methods. A cross-sectional analysis of a cohort study was conducted with a community-dwelling elderly population. The sample was a subset (N= 1559/1789) of participants in the Sacramento Area Latino Study on Aging (SALSA) ages 60-101 with available serum samples and functional impairment measures. Baseline serum samples were assayed for levels of immunoglobulin G antibodies to CMV and HSV-1 and for levels of CRP. Several measures were used to assess functional impairment, including activities of daily living (ADL), instrumental activities of daily living (IADL), and walking pace.Results. CMV and CRP showed statistically significant graded associations with ADL functional impairment, even after controlling for age and gender. The relationship between CMV and ADL was slightly attenuated, and the confidence interval contained the null value when adjusted for total number of health conditions, body mass index, and household income. Only high levels of CRP were significantly related to ADL and IADL impairment even after adjusting for all other covariates.Conclusion. Inflammation is clearly linked to physical functioning among aging Latinos. This study also suggests a role for CMV infection in relation to ADL impairment. Further research examining the influence of infection, immune response, and inflammation on longitudinal trajectories of physical functioning is warranted.