A Half-Subtractor Logic Circuit Based on the DNA Double Hairpin Structure
A Half-Subtractor Logic Circuit Based on the DNA Double Hairpin Structure
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基于DNA双发夹结构的半减器逻辑电路
DOI：
10.1166/jno.2018.2351
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发表时间：
2018
影响因子：
0.6
通讯作者：
Niu Ying
中科院分区：
文献类型：
--
作者：
Zhang Xuncai;Zhou Zheng;Wang Xi;Cui Guangzhao;Niu Ying
DNA互补碱基配对的精确性和可预测性使DNA纳米技术成为一种可靠的可编程控制方法，可以在纳米结构上实现具有数字和模拟行为的复杂反应网络。本文利用DNA双发夹结构设计了以支点为识别域的链置换反应，实现了与门、非门和异或门的基本逻辑运算，进而构建了半桥逻辑电路。通过仿真分析，证明了利用DNA双发夹结构构建分子逻辑电路的可行性和有效性。基于DNA双发夹结构的逻辑运算使得级联运算中发生泄漏反应的概率大大降低，为构造更复杂的逻辑电路提供了一种新的方法。
The accuracy and predictability of DNA complementary base pairing makes DNA nanotechnology a reliable and programmable control method, which can realize the complex reaction network with digital and analog behaviors on the nanostructure. In this paper, the DNA double hairpin structure was used to design the strand displacement reaction with the toehold as the recognition domain, which realized the basic logic operations of the AND gate, the NOT gate and the XOR gate, and then, the half-subtractor logic circuit was constructed. Through the simulation and analysis, the feasibility and effectiveness of constructing the molecular logic circuit by using the DNA double hairpin structure was proved. The logic operation based on the DNA double hairpin structure makes the probability of the leakage reaction in the cascade operation greatly reduced, which provides a new method for constructing more complex logic circuits.