ESTIMATION OF RELATIVE POTENCY WITH SEQUENTIAL DILUTION ERRORS IN RADIOIMMUNOASSAY
ESTIMATION OF RELATIVE POTENCY WITH SEQUENTIAL DILUTION ERRORS IN RADIOIMMUNOASSAY
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DOI：
10.2307/2532382
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发表时间：
1991-12-01
期刊：
影响因子：
1.9
通讯作者：
SMITH, AFM
中科院分区：
文献类型：
--
作者：
RACINEPOON, A;WEIHS, C;SMITH, AFM
连续稀释是放射免疫分析中非常常见的程序，其中稀释误差会从最高浓度到最低浓度累积。 相对效力测定中的模拟示例用于证明当模型中未正确包含稀释误差时可能得出的潜在错误结论。 使用贝叶斯方法并提出通过最大似然的替代近似。 建议采用替代实验设计来提高推断的精度。
Sequential dilution is a very common procedure in radioimmunoassay, in which the dilution error will be accumulated from the highest to the lowest concentration. A simulated example in relative potency determination is used to demonstrate the potentially wrong conclusion that can be drawn, when the dilution error is not properly included in the model. A Bayesian method is used and an alternative approximation via maximum likelihood is proposed. An alternative experimental design is recommended to increase the precision of the inference.