Regulation of translation initiation by RNA binding proteins.
Regulation of translation initiation by RNA binding proteins.
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DOI：
10.1146/annurev.micro.091208.073514
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发表时间：
2009
影响因子：
10.5
通讯作者：
Romeo T
中科院分区：
文献类型：
--
作者：
Babitzke P;Baker CS;Romeo T
RNA结合蛋白能够通过多种机制调节翻译起始。尽管绝大多数这些调节机制涉及翻译抑制，但翻译激活的一个例子已经被详细描述。这些调节蛋白的RNA识别靶标在结构复杂性上表现出广泛的多样性，一些蛋白质识别复杂的假结结构，另一些蛋白质结合简单的RNA发夹和/或短重复单链序列。在某些情况下，结合蛋白直接与核糖体结合竞争，在其他情况下，结合蛋白促进形成抑制核糖体结合的RNA结构。也存在这样的例子，即结合蛋白将核糖体困在一个不能启动翻译的复合体中。
RNA binding proteins are capable of regulating translation initiation by a variety of mechanisms. Although the vast majority of these regulatory mechanisms involve translational repression, one example of translational activation has been characterized in detail. The RNA recognition targets of these regulatory proteins exhibit a wide range in structural complexity, with some proteins recognizing complex pseudoknot structures and others binding to simple RNA hairpins and/or short repeated single-stranded sequences. In some instances the bound protein directly competes with ribosome binding, and in other instances the bound protein promotes formation of an RNA structure that inhibits ribosome binding. Examples also exist in which the bound protein traps the ribosome in a complex that is incapable of initiating translation.