Endocrine Disruptors and Obesity.
Endocrine Disruptors and Obesity.
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DOI：
10.1007/s13679-017-0240-4
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发表时间：
2017-03
影响因子：
8.8
通讯作者：
Darbre PD
中科院分区：
文献类型：
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作者：
Darbre PD
本综述的目的是总结目前的证据，即某些环境化学物质可能能够干扰能量代谢和脂肪组织结构的内分泌调节。最近的研究结果表明，这种被称为“肥胖源”的内分泌干扰化学物质可以促进脂肪生成并导致体重增加。这包括人们在日常生活中通过使用杀虫剂/除草剂、工业和家用产品、塑料、洗涤剂、阻燃剂以及作为个人护理产品的成分而接触到的化合物。动物模型和流行病学研究表明，宫内或新生儿期是接触的特别敏感时期。在总结致肥者的行为时，值得注意的是，由于它们的结构主要是亲脂的，它们增加脂肪沉积的能力也增加了它们自身保留的能力。这有可能形成恶性循环，不仅会增加肥胖，还会增加其他亲脂污染物的滞留，产生更广泛的不良反应。这可能会解释为什么肥胖是包括癌症在内的许多疾病的潜在风险因素。
The purpose of this review was to summarise current evidence that some environmental chemicals may be able to interfere in the endocrine regulation of energy metabolism and adipose tissue structure. Recent findings demonstrate that such endocrine-disrupting chemicals, termed “obesogens”, can promote adipogenesis and cause weight gain. This includes compounds to which the human population is exposed in daily life through their use in pesticides/herbicides, industrial and household products, plastics, detergents, flame retardants and as ingredients in personal care products. Animal models and epidemiological studies have shown that an especially sensitive time for exposure is in utero or the neonatal period. In summarising the actions of obesogens, it is noteworthy that as their structures are mainly lipophilic, their ability to increase fat deposition has the added consequence of increasing the capacity for their own retention. This has the potential for a vicious spiral not only of increasing obesity but also increasing the retention of other lipophilic pollutant chemicals with an even broader range of adverse actions. This might offer an explanation as to why obesity is an underlying risk factor for so many diseases including cancer.