Laryngeal sensation and pharyngeal delay time after (chemo)radiotherapy.
Laryngeal sensation and pharyngeal delay time after (chemo)radiotherapy.
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（化疗）放疗后喉部感觉和咽部延迟时间。
DOI：
10.1007/s00405-013-2775-7
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Nakashima T.
中科院分区：
文献类型：
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作者：
Maruo T.;Fujimoto Y.;Ozawa K.;Hiramatsu M.;Suzuki A.,Nishio N.;Nakashima T.
该研究的目的是评估(化疗)放疗前后喉部感觉的变化与吞咽反射或吞咽功能的启动之间的关系。一项前瞻性研究在一家三级转诊大学医院进行。13例接受(化疗)放射治疗的喉癌或下咽癌患者。在放疗前、化疗后1个月、3个月和1年后在会厌顶端评估喉部感觉。同时进行电视透视检查。定量测定包括喉部感觉的变化，咽延迟时间的计算机分析，舌骨偏移期舌骨运动的距离和速度，以及咽残留率(第一次吞咽时作为残留物留在咽部的团块的比例)。化疗后1个月喉部感觉明显恶化，但治疗1年后有恢复到治疗前水平的趋势。放疗前后咽部延迟时间和舌骨移位均无明显变化。此外，放疗前后第一次吞咽时舌骨平均运动速度和咽部淤积量均无显著差异。放化疗后，喉部感觉恶化。但是，在这项研究中，视频透视显示吞咽反射和功能保持不变。
The objective of the study was to evaluate the association between changes in laryngeal sensation and initiation of swallowing reflex or swallowing function before and after (chemo)radiotherapy. A prospective study was conducted in a tertiary referral university hospital. Thirteen patients who received (chemo)radiotherapy for treatment of laryngeal or hypopharyngeal cancer were included. Laryngeal sensation was evaluated at the tip of the epiglottis before and 1, 3 months, and 1 year after (chemo)radiotherapy. Videofluoroscopy was performed at the same time. Quantitative determinations included changes in laryngeal sensation, computed analysis of pharyngeal delay time, the distance and velocity of hyoid bone movement during the phase of hyoid excursion, and pharyngeal residue rate (the proportion of the bolus that was left as residue in the pharynx at the first swallow). Laryngeal sensation significantly deteriorated 1 month after (chemo)radiotherapy, but there was a tendency to return to pretreatment levels 1 year after treatment. Neither pharyngeal delay time nor displacement of the hyoid bone changed significantly before and after (chemo)radiotherapy. In addition, there was no significant difference in the mean velocity of hyoid bone movement and the amount of stasis in the pharynx at the first swallow before and after (chemo)radiotherapy. After (chemo)radiotherapy, laryngeal sensation deteriorated. But, in this study, videofluoroscopy showed that swallowing reflex and function were maintained.