Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering.
Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering.
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DOI：
10.1016/j.addr.2016.04.015
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发表时间：
2016-12-15
影响因子：
16.1
通讯作者：
Laurencin CT
中科院分区：
文献类型：
--
作者：
Narayanan G;Vernekar VN;Kuyinu EL;Laurencin CT
再生工程融合了组织工程、先进材料科学、干细胞科学和发育生物学，以再生整个肢体等复杂组织。再生工程支架提供机械支持和纳米级控制的架构，地形和生化线索，影响细胞的结果。在这方面，基于聚乳酸（PLA）的生物材料可被视为许多骨科再生工程应用的黄金标准，因为它们在制造、生物降解性以及与生物分子和细胞的相容性方面具有多功能性。在这里，我们讨论了PLA为基础的生物材料的可加工性和目前的应用在骨，韧带，半月板和软骨再生的临床和研究设置方面的最新进展。示意图说明了以烧结微球、电纺纳米纤维、多孔双相和3-D编织微纤维支架形式的基于PLA的生物材料用于骨、软骨、半月板和韧带再生的应用。
Regenerative engineering converges tissue engineering, advanced materials science, stem cell science, and developmental biology to regenerate complex tissues such as whole limbs. Regenerative engineering scaffolds provide mechanical support and nanoscale control over architecture, topography, and biochemical cues to influence cellular outcome. In this regard, poly (lactic acid) (PLA)-based biomaterials may be considered as a gold standard for many orthopaedic regenerative engineering applications because of their versatility in fabrication, biodegradability, and compatibility with biomolecules and cells. Here we discuss recent developments in PLA-based biomaterials with respect to processability and current applications in the clinical and research settings for bone, ligament, meniscus, and cartilage regeneration. A schematic illustrating the application of PLA based biomaterials in the form of sintered microspheres, electrospun nanofibers, porous biphasic, and 3-D braided microfiber scaffolds for bone, cartilage, meniscus, and ligament regeneration.