Suppression of inflammation by helminths: a role for the gut microbiota?
Suppression of inflammation by helminths: a role for the gut microbiota?
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DOI：
10.1098/rstb.2014.0296
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发表时间：
2015-08-19
期刊：
影响因子：
--
通讯作者：
Cantacessi C
中科院分区：
文献类型：
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作者：
Giacomin P;Croese J;Krause L;Loukas A;Cantacessi C
最近的多项研究强调了以蠕虫为基础的疗法有望用于治疗人类肠道的炎症性疾病，包括炎症性肠病和乳糜泻。然而，蠕虫调节免疫反应，导致慢性炎症症状改善的机制尚不清楚。鉴于肠道微生物区系在这些疾病的发病机制中的关键作用，人们假设蠕虫诱导的肠道共生菌群的改变可能对胃肠道寄生虫的治疗特性负责。在这篇文章中，我们综述了在慢性炎症动物模型和人类中宿主-寄生虫-微生物区系相互作用的最新研究进展，并提出了肠道微生物区系在蠕虫诱导的炎症抑制中的作用的工作假说。
Multiple recent investigations have highlighted the promise of helminth-based therapies for the treatment of inflammatory disorders of the intestinal tract of humans, including inflammatory bowel disease and coeliac disease. However, the mechanisms by which helminths regulate immune responses, leading to the amelioration of symptoms of chronic inflammation are unknown. Given the pivotal roles of the intestinal microbiota in the pathogenesis of these disorders, it has been hypothesized that helminth-induced modifications of the gut commensal flora may be responsible for the therapeutic properties of gastrointestinal parasites. In this article, we review recent progress in the elucidation of host–parasite–microbiota interactions in both animal models of chronic inflammation and humans, and provide a working hypothesis of the role of the gut microbiota in helminth-induced suppression of inflammation.