Heat‐killed bacillus Calmette–Guérin and Mycobacterium kansasii antigen 85B combined vaccination ameliorates dermatitis in a mouse model of atopic dermatitis by inducing regulatory T cells
Heat‐killed bacillus Calmette–Guérin and Mycobacterium kansasii antigen 85B combined vaccination ameliorates dermatitis in a mouse model of atopic dermatitis by inducing regulatory T cells
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DOI：
10.1111/j.1365-2133.2011.10763.x
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发表时间：
2012-05
影响因子：
10.3
通讯作者：
M. Kakeda;K. Yamanaka;H. Kitagawa;K. Tsuda;T. Akeda;I. Kurokawa;E. Gabazza;H. Mizutani
中科院分区：
文献类型：
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作者：
M. Kakeda;K. Yamanaka;H. Kitagawa;K. Tsuda;T. Akeda;I. Kurokawa;E. Gabazza;H. Mizutani
背景特应性皮炎(AD)是一种以辅助性T细胞(Th)2为主的细胞因子应答为特征的复发性炎症性皮肤病。卡介苗(BCG)已被用于预防结核病，并被认为是一种强大的Th1细胞因子诱导剂。抗原(Ag)85B是一种存在于分枝杆菌中的分泌性蛋白，可诱导Th1细胞因子的产生。
Background Atopic dermatitis (AD) is a recurrent inflammatory skin disease characterized by dominant T‐helper (Th) 2 cytokine response. Bacillus Calmette–Guérin (BCG) has been used for preventing tuberculosis, and is regarded as a strong Th1 cytokine inducer. Antigen (Ag) 85B is a secretory protein present in Mycobacterium species that induces Th1 cytokine production.