Pharmacological and immunological effects of individual herbs in the Food Allergy Herbal Formula-2 (FAHF-2) on peanut allergy
Pharmacological and immunological effects of individual herbs in the Food Allergy Herbal Formula-2 (FAHF-2) on peanut allergy
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DOI：
10.1002/ptr.2357
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发表时间：
2008-05-01
影响因子：
7.2
通讯作者：
Li, Xiu-Min
中科院分区：
文献类型：
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作者：
Kattan, Jacob D.;Srivastava, Kamal D.;Li, Xiu-Min
先前显示，由九种草药组成的中草药配方，食物过敏草药配方2（FAHF-2），在小鼠模型中阻断花生诱导的过敏反应。本研究旨在研究包含FAHF-2的单个草药对花生过敏的小鼠模型中花生诱导的过敏反应的药理作用，并确定是否所有九种草药都是预防过敏反应所必需的，或者是否含有较少草药的简化配方同样有效。一些草药可以减少花生引起的过敏症状，但没有一种草药可以提供与FAHF-2相当的过敏症状的完全保护。这些草药对组胺释放以及花生特异性血清IgE和IgG 2a水平具有高度可变的影响。草药对IL-4、IL-5和IFN-γ水平也有不同的影响。一个简化的配方，包括最有效的测试个别草药只显示出部分疗效，并不能够重现FAHF-2的效果，这表明FAHF-2的成分草药可能协同工作，产生由整个配方产生的疗效，这似乎是未来临床试验的最佳选择。版权所有（C）2008约翰威利父子有限公司
It was previously shown that a Chinese herbal formula, Food Allergy Herbal Formula 2 (FAHF-2) composed of nine herbs, blocked peanut-induced anaphylaxis in a murine model. The current study was designed to investigate the pharmacological actions of individual herbs comprising FAHF-2 on peanut-induced anaphylactic reactions in a murine model of peanut allergy and to determine if all nine herbs are necessary to prevent an anaphylactic reaction, or if a simplified formula containing fewer herbs would be equally effective. Some individual herbs reduced peanut-induced anaphylactic symptoms but no single herb offered full protection from anaphylactic symptoms equivalent to FAHF-2. The herbs had highly variable effects on histamine release, as well as peanut-specific serum IgE and IgG2a levels. The herbs also had variable effects on IL-4, IL-5 and IFN-gamma levels. A simplified formula comprising the most efficacious tested individual herbs showed only partial efficacy and was not able to reproduce comparably the effects of FAHF-2, suggesting that component herbs of FAHF-2 may work synergistically to produce the curative therapeutic effects produced by the whole formula, which appears to be the best option for future clinical trials. Copyright (C) 2008 John Wiley & Sons, Ltd.