General principles for systematic reviews and meta-analyses and a critique of a recent systematic review of long-acting β-agonists
General principles for systematic reviews and meta-analyses and a critique of a recent systematic review of long-acting β-agonists
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DOI：
10.1016/j.jaci.2006.11.632
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发表时间：
2007-02-01
影响因子：
14.2
通讯作者：
Chinchilli, Vernon M.
中科院分区：
文献类型：
--
作者：
Chinchilli, Vernon M.
系统综述试图总结与特定疾病的治疗、病因、诊断或预后相关的科学证据。荟萃分析是指系统评价中涉及统计分析的部分。该观点描述了系统评价和荟萃分析的适当步骤，并对最近关于长效β受体激动剂对严重哮喘急性发作和哮喘相关死亡的影响的系统评价进行了批评。本系统综述的作者确定了19项相关研究，并适当地应用了大多数方法步骤，尽管存在一些关于出版偏倚的担忧。作者发现，与安慰剂相比，长效β受体激动剂在严重哮喘急性发作、危及生命的哮喘急性发作和哮喘相关死亡方面的风险显著增加。在纳入系统性综述的19项研究中，沙美特罗多中心哮喘研究试验提供了80%的数据，在荟萃分析部分占主导地位，特别是在哮喘相关死亡方面。
systematic review attempts to summarize the scientific evidence related to treatment, causation, diagnosis, or prognosis of a specific disease. Meta-analysis refers to that portion of the systematic review that involves the statistical analysis. This perspective describes the appropriate steps in a systematic review and meta-analysis and critiques the recent systematic review on the effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. The authors of this systematic review identified 19 relevant studies and applied most of the methodological steps appropriately, although there is some concern about publication bias. The authors uncovered statistically significantly increased risk for long-acting beta-agonists compared with placebo with respect to severe asthma exacerbations, life-threatening asthma exacerbations, and asthma-related deaths. Out of the 19 studies included in the systematic review, the Salmeterol Multicenter Asthma Research Trial provided 80% of the data and dominated the meta-analysis component, especially with respect to asthma-related deaths.