Assessment of pedophilia using hemodynamic brain response to sexual stimuli.
Assessment of pedophilia using hemodynamic brain response to sexual stimuli.
复制标题
使用大脑对性刺激的血流动力学反应来评估恋童癖。
DOI：
10.1001/archgenpsychiatry.2011.130
复制
发表时间：
2012
影响因子：
--
通讯作者：
H. Bosinski
中科院分区：
文献类型：
--
作者：
J. Ponseti;O. Granert;O. Jansen;S. Wolff;K. Beier;J. Neutze;G. Deuschl;H. Mehdorn;H. Siebner;H. Bosinski
上下文
准确评估性偏好在儿童性犯罪者的治疗中很重要。测量法是确定性取向的标准方法；然而，这种测量方法因其侵入性和有限的可靠性而受到批评。
客观化
评价血氧水平依赖信号的变化所揭示的对性刺激的空间反应模式是否有助于鉴定恋童癖。
设计
在功能磁共振成像期间，恋童癖和非恋童癖参与者被短暂地暴露在同性和异性裸体儿童和成人的图像中。我们计算了每个参与者对儿童和成人性刺激的血氧水平依赖信号的差异。将相应的对比度图像输入到组分析中，计算组间的全脑差异图。我们为每个参与者计算与组结果相对应的表达式值。这些表达值被提交给两种不同的分类算法：Fiser线性判别分析和κ最近邻分析。这一分类程序使用留一法进行交叉验证。
设置
德国基尔克里斯蒂安·阿尔布雷希茨大学医学院性医学部。
参与者
我们招募了24名有恋童癖的参与者，他们被青春期前女孩(n=11)或青春期前男孩(n=13)性吸引，而32名健康男性对照组则被成年女性(n=18)或成年男性(n=14)性吸引。
主要结果衡量标准
两种分类算法的灵敏度和特异度得分。
结果
Fisher线性判别分析的分类准确率最高，平均准确率为95%(特异度为100%，敏感度为88%)。
结论
大脑对性刺激的功能性反应模式包含了足够的信息，可以高精度地识别恋童癖。这些模式的自动分类是临床诊断恋童癖的一种很有前途的客观工具。
CONTEXT
Accurately assessing sexual preference is important in the treatment of child sex offenders. Phallometry is the standard method to identify sexual preference; however, this measure has been criticized for its intrusiveness and limited reliability.
OBJECTIVE
To evaluate whether spatial response pattern to sexual stimuli as revealed by a change in the blood oxygen level-dependent signal facilitates the identification of pedophiles.
DESIGN
During functional magnetic resonance imaging, pedophilic and nonpedophilic participants were briefly exposed to same- and opposite-sex images of nude children and adults. We calculated differences in blood oxygen level-dependent signals to child and adult sexual stimuli for each participant. The corresponding contrast images were entered into a group analysis to calculate whole-brain difference maps between groups. We calculated an expression value that corresponded to the group result for each participant. These expression values were submitted to 2 different classification algorithms: Fisher linear discriminant analysis and κ -nearest neighbor analysis. This classification procedure was cross-validated using the leave-one-out method.
SETTING
Section of Sexual Medicine, Medical School, Christian Albrechts University of Kiel, Kiel, Germany.
PARTICIPANTS
We recruited 24 participants with pedophilia who were sexually attracted to either prepubescent girls (n = 11) or prepubescent boys (n = 13) and 32 healthy male controls who were sexually attracted to either adult women (n = 18) or adult men (n = 14).
MAIN OUTCOME MEASURES
Sensitivity and specificity scores of the 2 classification algorithms.
RESULTS
The highest classification accuracy was achieved by Fisher linear discriminant analysis, which showed a mean accuracy of 95% (100% specificity, 88% sensitivity).
CONCLUSIONS
Functional brain response patterns to sexual stimuli contain sufficient information to identify pedophiles with high accuracy. The automatic classification of these patterns is a promising objective tool to clinically diagnose pedophilia.
影响因子：
--
作者：
Koutsouleris, Nikolaos;Meisenzahl, Eva M.;Davatzikos, Christos;Bottlender, Ronald;Frodl, Thomas;Scheuerecker, Johanna;Schmitt, Gisela;Zetzsche, Thomas;Decker, Petra;Reiser, Maximilian;Moeller, Hans-Juergen;Gaser, Christian
通讯作者：
Gaser, Christian
影响因子：
14.5
作者：
Kloeppel, Stefan;Stonnington, Cynthia M.;Chu, Carlton;Draganski, Bogdan;Scahill, Rachael I.;Rohrer, Jonathan D.;Fox, Nick C.;Jack, Clifford R., Jr.;Ashburner, John;Frackowiak, Richard S. J.
通讯作者：
Frackowiak, Richard S. J.