Neonatal ventral hippocampal lesions in male and female rats: Effects on water maze, locomotor activity, plus-maze and prefrontal cortical GABA and glutamate release in adulthood
Neonatal ventral hippocampal lesions in male and female rats: Effects on water maze, locomotor activity, plus-maze and prefrontal cortical GABA and glutamate release in adulthood
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DOI：
10.1016/j.bbr.2009.03.044
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发表时间：
2009-09-14
影响因子：
2.7
通讯作者：
Jhamandas, Khem
中科院分区：
文献类型：
--
作者：
Beninger, Richard J.;Tuerke, Katharine J.;Jhamandas, Khem
精神分裂症的特点是不同的行为和神经化学异常，可能是差异表达的男性和女性。新生儿腹侧海马病变（nVHL）的雄性大鼠通常表现出类似于精神分裂症的行为和神经化学异常。使用雌性大鼠的研究较少。我们研究了这一假设，即雄性和雌性nVHL大鼠将表现出行为异常，伴随着减少GABA和L-谷氨酸释放的前额叶皮层（PFC）。在出生后第（P）天，7只大鼠接受鹅膏蕈氨酸（3.0 μ g/03 μ l/侧; n = 18）或盐水（n = 21）的VH注射或不注射（n = 22）。于P56开始水迷宫、活动性运动和高架十字迷宫实验，然后处死大鼠，检测钾诱发的PFC脑片GABA和L-谷氨酸释放。nVHL大鼠在水迷宫获取和匹配样本任务中表现出受损的表现，自发和苯丙胺诱导的运动活动增加，开放臂时间百分比增加。这些行为变化在雄性和雌性中相似。与对照组相比，这些效应伴随着雄性和雌性nVHL大鼠钾诱发的L-谷氨酸释放显著减少，GABA释放无显著降低。研究结果支持这样的观点，即青春期后的男性和女性nVHL大鼠的行为异常与PFC神经递质释放减少。(C)2009爱思唯尔有限公司版权所有。
Schizophrenia is characterized by diverse behavioural and neurochemical abnormalities that may be differentially expressed in males and females. Male rats with neonatal ventral hippocampal lesions (nVHL) have commonly demonstrated behavioural and neurochemical abnormalities similar to those in schizophrenia. Fewer studies have used female rats. We investigated the hypothesis that male and female nVHL rats will demonstrate behavioural abnormalities accompanied by decreased GABA and L-glutamate release in the prefrontal cortex (PFC). On postnatal day (P) 7 rats received VH injections of ibotenate (3.0 mu g/03 mu l/side; n = 18) or saline (n = 21) or no injections (n = 22). On P56, rats began water-maze, locomotor for activity and elevated plus maze testing, and were then sacrificed for potassium-evoked GABA and L-glutamate release from PFC slices. nVHL rats showed impaired performance in water maze acquisition and match-to-sample tasks, increased spontaneous and amphetamine-induced locomotor activity and increased percent open-arm time. These behavioural changes were similar in males and females. These effects were accompanied by significantly reduced potassium-evoked L-glutamate release in male and female nVHL rats relative to controls, and non-significantly lower GABA release. Findings support the notion that behavioural abnormalities in post-pubertal male and female nVHL rats are associated with decreases in PFC reurotransmitter release. (C) 2009 Elsevier B.V. All rights reserved.