PHYSIOLOGICAL CONSEQUENCES OF INCREASED VASCULAR OXIDANT STRESSES IN HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS - IMPLICATIONS FOR IMPAIRED VASOMOTION
PHYSIOLOGICAL CONSEQUENCES OF INCREASED VASCULAR OXIDANT STRESSES IN HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS - IMPLICATIONS FOR IMPAIRED VASOMOTION
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DOI：
10.1016/0002-9149(95)80018-n
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发表时间：
1995-02-23
影响因子：
2.8
通讯作者：
OHARA, Y
中科院分区：
文献类型：
--
作者：
HARRISON, DG;OHARA, Y
在过去的8年中，内皮依赖性血管舒张在多种疾病状态下是异常的，包括高胆固醇血症、动脉粥样硬化、糖尿病、高血压和心脏移植后。我们实验室和其他几个实验室已经研究了高胆固醇血症和动脉粥样硬化中血管紧张素的功能失调调节。这些研究导致了这样的概念，即内皮对血管运动的调节改变（1）是动脉粥样硬化的早期发展，（2）涉及两条大血管（明显动脉粥样硬化）和微循环（其中动脉粥样硬化不发展），和（3）可以通过降脂策略逆转，这种形式的内皮功能障碍的异常机制可能是多因素的，但一个主要的潜在因素似乎是内皮源性一氧化氮的氧化降解增加，在这篇综述中，我们研究了支持这一结论的证据，并考虑这些发现的影响。
During the past 8 years, it has become apparent that endothelium-dependent vascular relaxation is abnormal in a variety of disease states, including hypercholesterolemia, atherosclerosis, diabetes, hypertension, and following heart transplantation. Our laboratory and several others have examined dysfunctional regulation of vasomotor tone in hypercholesterolemia and atherosclerosis. These studies have led to the concepts that altered regulation of vasomotion by the endothelium (1) Is an early development in atherosclerosis, (2) involves both large vessels (with overt atherosclerosis) and the microcirculation (in which atherosclerosis does not develop), and (3) can be reversed by lipid-lowering strategies, The mechanisms for the abnormalities underlying this form of endothelial dysfunction are likely multifactorial, but a major underlying factor appears to be increased oxidant degradation of endothelium-derived nitric oxide, In this review we examine the evidence supporting this conclusion and consider the implications of these findings.