Statistical harmonization of everyday functioning and dementia-related behavioral measures across nine surveys and trials.
Statistical harmonization of everyday functioning and dementia-related behavioral measures across nine surveys and trials.
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DOI：
10.1002/dad2.12412
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发表时间：
2023-01
期刊：
影响因子：
--
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中科院分区：
文献类型：
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在痴呆症研究中，为了综合各项研究，需要努力统一日常功能和与痴呆相关行为的衡量标准。在二次分析中，已经有一些心理测量方面的尝试来统一日常功能，但针对与痴呆相关行为的尝试要少得多。
进行了统计协同校准，以便为痴呆症患者生成代表日常功能和与痴呆相关行为的因子分数。我们评估了因子分数的收敛效度标准，并将这些分数映射到已有的临床工具上。
对纳入项目的因子分析与现有数据拟合良好。统一后的因子显示出与全球临床痴呆评定（CDR）分数的预期关联，即损伤越严重（全球CDR分数越高），因子分数越高（病情越严重）。
我们使用大量特征明确的样本推导出代表日常功能和与痴呆相关行为的统一因子。这些统一因子可用于解决有关痴呆表型的问题，这些问题要么需要大样本，要么需要独特的亚人群。
Efforts to harmonize measures of everyday function and dementia‐related behaviors are needed to synthesize across studies in dementia research. There have been some psychometric attempts to harmonize everyday function for secondary analysis, but far less for dementia‐related behaviors. Statistical co‐calibration was performed to generate factor scores representing everyday function and dementia‐related behaviors for participants with dementia. We evaluated convergent criterion validity of factor scores and mapped the scores onto established clinical instruments. Factor analyses of included items fit well to available data. Harmonized factors showed expected associations with the Global Clinical Dementia Rating (CDR) score, with greater impairment (higher Global CDR score) corresponding to higher (more severe) levels on factor scores. We used large, well‐characterized samples to derive harmonized factors representing everyday functions and dementia‐related behaviors. These harmonized factors can be used to tackle questions about dementia phenotypes which require either large samples or unique subpopulations.
影响因子：
4
作者：
Chen D;Jutkowitz E;Iosepovici SL;Lin JC;Gross AL
通讯作者：
Gross AL