How to Handle a CA-MRSA Outbreak
How to Handle a CA-MRSA Outbreak
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DOI：
10.1016/j.det.2008.07.005
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发表时间：
2009-01-01
影响因子：
2.4
通讯作者：
Elston, Dirk M.
中科院分区：
文献类型：
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作者：
Elston, Dirk M.
由于日托中心和运动队成员中大规模爆发，社区获得性耐甲氧西林金黄色葡萄球菌 (CA-MRSA) 继续成为头条新闻。儿童 CA-MRSA 感染通常会导致住院治疗。可能会发生危及生命的感染，例如坏死性肺炎和脑脓肿。这种微生物已经进入医院，现在是医院获得性败血症的常见原因。 MRSA 多重耐药菌株正在亚洲出现，其耐药性基于新型基因盒或可传播质粒。牲畜中抗生素的常规使用似乎导致了耐药微生物的出现，其中一些已经引起了人类感染。幸运的是，大多数皮肤 CA-MRSA 感染表现为脓肿或疖肿，这些表现通常对引流有反应。密切接触者的复发率和发病率很高，并且与持续定植有关。
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) continues to make headlines because of large outbreaks in daycare centers and among members of athletic teams. CA-MRSA infections in children commonly lead to hospitalization. Life-threatening infections, such as necrotizing pneumonitis and brain abscess, can occur. The organism has crossed into hospitals and is now a common cause of hospital-acquired sepsis. Multidrug-resistant strains of MRSA are emerging in Asia, with the resistance based on either a novel gene cassette or a transmissible plasmid. The routine use of antibiotics in livestock seems to be contributing to the emergence of resistant organisms, and some of these have already produced human infection. Fortunately, most cutaneous CA-MRSA infections present as abscesses or furunculosis, and these manifestations generally respond to drainage. The recurrence and attack rates of close contacts are high and relate to persistent colonization.