Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.
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DOI：
10.1021/acs.chemrev.5b00299
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发表时间：
2015-12-23
期刊：
影响因子：
62.1
通讯作者：
Xu B
中科院分区：
文献类型：
--
作者：
Du X;Zhou J;Shi J;Xu B
本文综述了2004年以后超分子水凝胶的研究进展，重点介绍了超分子水凝胶作为分子生物材料的应用。在简要介绍了超分子水凝胶的制备方法之后，我们根据超分子水凝胶因子的种类，如有机小分子、配位络合物、肽类、核碱基和配位体，对它们进行了讨论。分子设计之后，我们专注于超分子水凝胶作为分子生物材料的各种潜在应用，按其在细胞培养，组织工程，细胞行为，成像和水凝胶剂的独特应用进行分类。特别是，我们讨论了超分子水凝胶因子的应用后，他们形成超分子组件，但在达到临界凝胶化浓度之前，因为这个问题是较少探索，但可能同样有很大的希望，帮助解决有关的机制或分子的自组装的后果的基本问题，包括低分子量的。最后，我们提供了一个超分子水凝胶因子的前景。我们希望这篇评论将作为一个更新的介绍和参考研究人员谁有兴趣探索超分子水凝胶分子生物材料，以满足社会需求的各个前沿。
In this review we intend to provide a relatively comprehensive summary of the work of supramolecular hydrogelators after 2004 and to put emphasis particularly on the applications of supramolecular hydrogels/hydrogelators as molecular biomaterials. After a brief introduction of methods for generating supramolecular hydrogels, we discuss supramolecular hydrogelators on the basis of their categories, such as small organic molecules, coordination complexes, peptides, nucleobases, and saccharides. Following molecular design, we focus on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators. Particularly, we discuss the applications of supramolecular hydrogelators after they form supramolecular assemblies but prior to reaching the critical gelation concentration because this subject is less explored but may hold equally great promise for helping address fundamental questions about the mechanisms or the consequences of the self-assembly of molecules, including low molecular weight ones. Finally, we provide a perspective on supramolecular hydrogelators. We hope that this review will serve as an updated introduction and reference for researchers who are interested in exploring supramolecular hydrogelators as molecular biomaterials for addressing the societal needs at various frontiers.