Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland
Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland
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DOI：
10.1056/nejmoa030595
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发表时间：
2004-02-26
影响因子：
158.5
通讯作者：
Steffen, R
中科院分区：
文献类型：
--
作者：
Mutsch, M;Zhou, WG;Steffen, R
背景：在引入仅在瑞士使用的鼻内灭活流感疫苗后，46例贝尔麻痹病例被报道。方法：我们进行了匹配的病例对照研究和病例系列分析。瑞士德语区的所有初级保健医生、耳鼻喉科专家和神经科医生被要求识别2000年10月1日至2001年4月30日期间在成人中诊断的贝尔麻痹病例。每位医生被邀请为每位贝尔麻痹患者选择三名对照患者，根据年龄，诊所就诊日期和医生进行匹配。疫苗接种信息由医生提供。结果：共确定了773例贝尔麻痹患者。在412名（53.3%）可以评估的患者中，250名（60.7%）被招募并与722名对照患者匹配;其他162名患者没有对照。在病例对照研究中，我们发现68名贝尔麻痹患者（27.2%）和8名对照（1.1%）接受了鼻内疫苗（P
BACKGROUND:After the introduction of an inactivated intranasal influenza vaccine that was used only in Switzerland, 46 cases of Bell's palsy were reported.METHODS:We conducted a matched case-control study and a case-series analysis. All primary care physicians, ear, nose, and throat specialists, and neurologists in German-speaking regions of Switzerland were requested to identify cases of Bell's palsy diagnosed in adults between October 1, 2000, and April 30, 2001. Each physician was invited to select three control patients for each patient with Bell's palsy, with matching according to age, date of the clinic visit, and physician. Vaccination information was provided by the physicians.RESULTS:A total of 773 patients with Bell's palsy were identified. Of the 412 (53.3 percent) who could be evaluated, 250 (60.7 percent) were enrolled and matched with 722 control patients; the other 162 patients had no controls. In the case-control study, we found that 68 patients with Bell's palsy (27.2 percent) and 8 controls (1.1 percent) had received the intranasal vaccine (P