HCV genotype profile in Brazil of mono-infected and HIV co-infected individuals: A survey representative of an entire country
HCV genotype profile in Brazil of mono-infected and HIV co-infected individuals: A survey representative of an entire country
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DOI：
10.1371/journal.pone.0227082
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发表时间：
2020-01-06
期刊：
影响因子：
3.7
通讯作者：
Diaz, Ricardo Sobhie
中科院分区：
文献类型：
--
作者：
Rodrigues Nutini, Mariana Fernanda;Hunter, James;Diaz, Ricardo Sobhie
在巴西，为了获得政府提供的治疗资格，所有HCV感染者都必须在诊断后不久进行基因分型。我们描述了HCV基因型（G）的地理区域，性别，年龄和HIV合并infection.MethodsWe评估了29，071从2016年3月至2018年3月收集的HCV感染者的基因型（雅培实时HCV基因型）。我们使用EIA快速检测试剂盒（TR DPP HIV 1/2 Bio-Manguinhos）随机选择了1/2，336份样本进行HIV合并感染检测。结果总的来说，HCV基因型分布为G1 A 40.9%，G1 B 30.2%，G3 23.8%，G2 3.8%，G4 0.7%，G5 0.1%和多基因型0.6%。男性G1 A患病率为44.4%，女性为35.8%。G1 B和G2在老年人中比G1 A和G3更普遍。G3在南部地区更为普遍。在检测艾滋病毒合并感染的样本中，15%为艾滋病毒阳性。HCV/HIV合并感染者的中位年龄为50岁，而单一感染者为57岁。HCV/HIV共感染者与HCV单一感染者的HCV基因型分布分别为：G1 A型60.6%与37.8%、G1 B型15.2%与32.9%、G3型18.9%与24.7%。在合并感染的年轻男性中检测到G4（3.5%与0.2%之间的mononinfected）.ConclusionThe G3的患病率增加，推断年龄较小的HCV感染者，构成了一个额外的挑战，关于疾病的进展。HCV单一感染和HCV/HIV合并感染之间不同的基因型特征值得进一步研究，以更好地了解和帮助减轻HCV传播链。
IntroductionTo be eligible for government-provided treatment in Brazil, all HCV-infected individuals are required to be genotyped shortly after diagnosis. We describe the HCV genotype (G) profiles by geographic region, gender, age and HIV co-infection.MethodsWe assessed 29,071 genotypes collected from HCV-infected individuals from March 2016 to March 2018 (Abbott Real-Time HCV Genotype). We randomly selected 12,336 samples for HIV co-infection testing using an EIA rapid test kit (TR DPP HIV 1/2 Bio-Manguinhos). Descriptive statistical analyses were performed using R.ResultsOverall, HCV genotype distribution was 40.9% G1A, 30.2% G1B, 23.8% G3, 3.8% G2, 0.7% G4, 0.1% G5 and 0.6% with multiples genotypes. G1A prevalence was 44.4% among males and 35.8% among females. G1B and G2 were more prevalent in older individuals than G1A and G3. G3 was more prevalent in the South region. Of samples tested for HIV co-infection, 15% were HIV+. Median age among HCV/HIV co-infected individuals was 50 years old compared to 57 years old among mono-infected individuals. Distinct HCV genotype prevalence between HCV/HIV co-infected and HCV mono-infected individuals were respectively: G1A 60.6% versus 37.8%, G1B 15.2% versus 32.9%, and G3 18.9% versus 24.7%. G4 was detected among co-infected young men (3.5% versus 0.2% among monoinfected).ConclusionThe increasing prevalence of G3, as inferred by the younger ages of the HCV-infected individuals, poses an extra challenge with regards to disease progression. Distinct genotypical profiles between HCV mono-infection and HCV/HIV co-infection warrant future research in order to better understand and help mitigate HCV chains of transmission.