Application of a 2-aryl indenylphosphine ligand in the Buchwald-Hartwig cross-coupling reactions of aryl and heteroaryl chlorides under the solvent-free and aqueous conditions
Application of a 2-aryl indenylphosphine ligand in the Buchwald-Hartwig cross-coupling reactions of aryl and heteroaryl chlorides under the solvent-free and aqueous conditions
复制标题
2-芳基茚基膦配体在无溶剂和水条件下芳基和杂芳基氯化物的Buchwald-Hartwig交叉偶联反应中的应用
DOI：
10.1039/c7ob01199g
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发表时间：
2017
影响因子：
3.2
通讯作者：
Yu Guang Ao
中科院分区：
文献类型：
--
作者：
Liu Yan;Yuan Jia;Wang Zi Fei;Zeng Si Hao;Gao Meng Yue;Ruan Mei Lin;Chen Jian;Yu Guang Ao
在Pd（dba）2/ligand 1催化体系下，芳基和杂芳基氯与伯胺和仲胺的Buchwald-Hartwig偶联反应在无溶剂条件下进行.值得注意的是，该催化体系在水性条件下也有效地催化反应。
An efficient solvent-free protocol for the Buchwald–Hartwig cross-coupling reaction of aryl and heteroaryl chlorides with primary and secondary amines using the Pd(dba)2/ligand 1 catalytic system has been developed. Notably, the catalytic system also efficiently catalyzed the reaction under aqueous conditions.