Synaptic plasticity and pain aversion
Synaptic plasticity and pain aversion
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DOI：
10.1016/j.ejphar.2011.05.080
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发表时间：
2011-09-30
影响因子：
5
通讯作者：
Naguib, Mohamed
中科院分区：
文献类型：
--
作者：
Bie, Bihua;Brown, David L.;Naguib, Mohamed
消极情感被定义为痛苦的概念特征。许多临床和动物研究表明，包括前扣带皮层（ACC）和杏仁核在内的边缘系统在处理疼痛的情感成分中起着关键作用。谷氨酸传递在疼痛的情感方面的加工中起着重要作用。谷氨酸突触的长期变化有助于疼痛引起的厌恶行为的表达。本文将对参与疼痛情感方面处理的神经回路、这些脑区谷氨酸能突触可塑性以及疼痛相关突触可塑性的表观遗传机制进行综述和讨论。关于突触可塑性与疼痛的情感成分之间相互作用的新发现可能会促进我们对疼痛机制的理解，并导致新的疼痛治疗策略。(C) 2011 Elsevier B.V.版权所有
Negative affective emotions are defined as the conceptual feature of pain. A number of clinical and animal studies have indicated that the limbic system including the anterior cingulate cortex (ACC) and amygdala plays a critical role in the processing of affective components of pain. Glutamatergic transmission plays an important role in the processing of affective aspects of pain. Long-term changes on glutamatergic synapses contribute to the expression of aversion behavior induced by pain. In this article, the neurocircuits involved in the processing of affective aspects of pain, the glutamatergic synaptic plasticity in these brain regions, and the epigenetic mechanisms underlying pain-related synaptic plasticity will be reviewed and discussed. New discoveries regarding the interaction between the synaptic plasticity and affective components of pain may advance our understanding on the pain mechanism, and lead to new strategies for pain treatment. (C) 2011 Elsevier B.V. All rights reserved.