CD54-Mediated Interaction with Pro-inflammatory Macrophages Increases the Immunosuppressive Function of Human Mesenchymal Stromal Cells.
CD54-Mediated Interaction with Pro-inflammatory Macrophages Increases the Immunosuppressive Function of Human Mesenchymal Stromal Cells.
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DOI：
10.1016/j.stemcr.2017.02.008
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发表时间：
2017-04-11
影响因子：
5.9
通讯作者：
Varin A
中科院分区：
文献类型：
--
作者：
Espagnolle N;Balguerie A;Arnaud E;Sensebé L;Varin A
间充质基质细胞（MSC）感知和调节炎症，并代表免疫疾病的潜在临床治疗。然而，骨髓间充质干细胞和先天免疫区室的双向相互作用的许多细节仍然没有解决。在这里，我们描述了一种非常规的，但功能性的相互作用之间的促炎经典激活的巨噬细胞（M1 M Φ）和MSC，与CD 54发挥核心作用。CD 54在M1 M CD 4+与MSC的接触区域特异性地被上调和富集。此外，特异性相互作用诱导钙信号传导并增加依赖于CD 54介导的MSC的免疫抑制能力。我们的数据表明，MSC可以通过与先天免疫细胞的直接和物理相互作用来检测炎症微环境。这一发现为基于MSC的细胞治疗开辟了不同的前景。间充质干细胞（MSC）与基质细胞之间的非常规但功能性的相互作用CD 54依赖性的M1 M β-MSC相互作用增加MSC免疫抑制特性基质细胞与MΦ间充质基质细胞（MSC）之间的物理相互作用的首次表征有望通过关闭免疫应答用于炎性疾病的基于细胞的治疗。Varin及其同事证明，MSC和炎性巨噬细胞通过非常规但功能性的相互作用进行交流，这种相互作用强烈增强了MSC的免疫抑制能力。先天免疫系统和MSC之间的这种新的交流为基于MSC的细胞治疗开辟了新的前景。
Mesenchymal stromal cells (MSCs) sense and modulate inflammation and represent potential clinical treatment for immune disorders. However, many details of the bidirectional interaction of MSCs and the innate immune compartment are still unsolved. Here we describe an unconventional but functional interaction between pro-inflammatory classically activated macrophages (M1MΦ) and MSCs, with CD54 playing a central role. CD54 was upregulated and enriched specifically at the contact area between M1MФ and MSCs. Moreover, the specific interaction induced calcium signaling and increased the immunosuppressive capacities of MSCs dependent on CD54 mediation. Our data demonstrate that MSCs can detect an inflammatory microenvironment via a direct and physical interaction with innate immune cells. This finding opens different perspectives for MSC-based cell therapy. Unconventional but functional interaction between M1MФ and MSCs CD54-dependent M1MФ-MSC interaction increases MSC immunosuppressive properties First characterization of physical interaction between stromal cells and MΦ Mesenchymal stromal cells (MSCs) are promising for cell-based therapy in inflammatory disorders by switching off the immune response. Varin and colleagues demonstrate that MSCs and inflammatory macrophages communicate via an unconventional but functional interaction that strongly increases the immunosuppressive capacities of MSCs. This new communication between the innate immune system and MSCs opens new perspectives for MSC-based cell therapy.