The number of years lived with obesity and the risk of all-cause and cause-specific mortality
The number of years lived with obesity and the risk of all-cause and cause-specific mortality
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DOI：
10.1093/ije/dyr018
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发表时间：
2011-08-01
影响因子：
7.7
通讯作者：
Peeters, Anna
中科院分区：
文献类型：
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作者：
Abdullah, Asnawi;Wolfe, Rory;Peeters, Anna
肥胖持续时间作为死亡率的独立危险因素的作用尚未被调查。这项研究的目的是分析肥胖持续时间与死亡风险之间的关系。方法从1948年开始，每2年对Framingham队列研究的5036例参与者（28-62岁）进行随访，随访时间长达48年。使用随时间变化的Cox模型对体重指数进行调整，分析肥胖持续时间与全因死亡率和病因特异性死亡率之间的关系。还探讨了生物中间体和慢性病的作用。结果调整后的死亡率风险比（HR）随着肥胖生存年限的增加而增加。在研究随访期1-4.9年、5-14.9年、15-24.9年和25年的肥胖者中，与非肥胖者相比，调整后全因死亡率hr分别为1.51[95%可信区间（CI） 1.27-1.79]、1.94 （95% CI 1.71-2.20）、2.25 （95% CI 1.89-2.67）和2.52 （95% CI 2.08-3.06）。在全因死亡率、心血管死亡率、癌症死亡率和其他原因死亡率中，肥胖持续时间之间的剂量-反应关系也很明显。每增加2年的肥胖，全因、心血管疾病、癌症和其他原因死亡率的hr分别为1.06 （95% CI 1.05-1.07）、1.07 （95% CI 1.05-1.08）、1.03 （95% CI 1.01-1.05）和1.07 （95% CI 1.05-1.11）。结论肥胖生活年数与死亡风险直接相关。在估计其死亡率负担时需要考虑到这一点。
Background The role of the duration of obesity as an independent risk factor for mortality has not been investigated. The aim of this study was to analyse the association between the duration of obesity and the risk of mortality.Methods A total of 5036 participants (aged 28-62 years) of the Framingham Cohort Study were followed up every 2 years from 1948 for up to 48 years. The association between obesity duration and all-cause and cause-specific mortality was analysed using time-dependent Cox models adjusted for body mass index. The role of biological intermediates and chronic diseases was also explored.Results The adjusted hazard ratio (HR) for mortality increased as the number of years lived with obesity increased. For those who were obese for 1-4.9, 5-14.9, 15-24.9 and epsilon 25 years of the study follow-up period, adjusted HRs for all-cause mortality were 1.51 [95% confidence interval (CI) 1.27-1.79], 1.94 (95% CI 1.71-2.20), 2.25 (95% CI 1.89-2.67) and 2.52 (95% CI 2.08-3.06), respectively, compared with those who were never obese. A dose-response relation between years of duration of obesity was also clear for all-cause, cardiovascular, cancer and other-cause mortality. For every additional 2 years of obesity, the HRs for all-cause, cardiovascular disease, cancer and other-cause mortality were 1.06 (95% CI 1.05-1.07), 1.07 (95% CI 1.05-1.08), 1.03 (95% CI 1.01-1.05) and 1.07 (95% CI 1.05-1.11), respectively.Conclusions The number of years lived with obesity is directly associated with the risk of mortality. This needs to be taken into account when estimating its burden on mortality.