Amplification of epidermal growth factor receptor gene in renal cell carcinoma
Amplification of epidermal growth factor receptor gene in renal cell carcinoma
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DOI：
10.1016/j.ejca.2010.01.011
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发表时间：
2010-03-01
影响因子：
8.4
通讯作者：
Hawkins, Robert E.
中科院分区：
文献类型：
--
作者：
El-Hariry, Iman;Powles, Thomas;Hawkins, Robert E.
表皮生长因子受体（埃格）的表达可能是肾细胞癌（RCC）的预后价值。在先前报道的一项随机研究中，对315例晚期RCC患者的埃格基因扩增进行了研究。使用荧光原位杂交，只有2例患者（0.6%）有基因扩增，因此基因扩增是没有预后价值的RCC。(C)2010爱思唯尔有限公司版权所有，
Expression of epidermal growth factor receptor (EGER) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGER was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC. (C) 2010 Elsevier Ltd. All rights reserved,