Heritability of Level of Response and Association with Recent Drinking History in Nonalcohol-Dependent Drinkers
Heritability of Level of Response and Association with Recent Drinking History in Nonalcohol-Dependent Drinkers
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DOI：
10.1111/j.1530-0277.2011.01699.x
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发表时间：
2012-06-01
影响因子：
3.2
通讯作者：
Taylor, Robert
中科院分区：
文献类型：
--
作者：
Kalu, Nnenna;Ramchandani, Vijay A.;Taylor, Robert
背景资料：对酒精的反应水平（LR）已被证明与发展酒精依赖的风险有关，可以使用酒精影响的自我评定（SRE）问卷进行测量。本研究探讨了SRE测量的LR的遗传性和LR和最近的饮酒史（RDH）在一个主要是非洲裔美国人的非酒精依赖人群之间的关系。方法：这是一项对101名来自华盛顿大都会区的21 - 35岁社交饮酒者的同胞研究。参与者接受SRE评估LR和时间轴随访（TLFB）评估RDH。SRE指标包括SRE总分（SRTT）、早期饮酒SRE评分（SRED）、经常饮酒SRE评分（SRRD）和大量饮酒SRE评分（SRHD）。皮尔森的积差相关和线性回归被用来分析SRE指数和RDH变量（每次饮酒的数量和饮料）。遗传力分析使用顺序寡基因连锁分析软件（SOLAR）与SRE指数作为感兴趣的性状。结果：SRE和RDH测量值之间存在显著相关。每天饮酒量、最大饮酒量和饮酒量与SRTT、SRHD和SRRD显著相关（均p < 0.05）。SRTT表现出显著的遗传力（h ~ 2 = 0.67，p = 0.025），而SRE亚指标（SRED，SRRD，SRHD）的遗传力不显著。在仅由非洲裔美国人（n = 86）组成的子集中进行的分析显示出相似的趋势。结论：由SRE测量的LR与RDH相关。SRE总分的高水平遗传性表明，遗传因素在社交饮酒者对酒精的LR变异中占很大比例。
Background: Level of response (LR) to alcohol has been shown to be associated with the risk of developing alcohol dependence and can be measured using the self-rating of the effects of alcohol (SRE) questionnaire. This study examined the heritability of the SRE-measured LR and the relationship between LR and recent alcohol drinking history (RDH) in a predominantly African American nonalcohol-dependent population. Methods: This was a sibling study of 101 social drinkers aged 21 to 35 years recruited from the Washington, DC metropolitan area. Participants were administered the SRE to assess LR and the timeline followback (TLFB) to assess RDH. The indices of SRE used were total SRE score (SRTT), early drinking SRE score (SRED), regular drinking SRE score (SRRD), and heavy drinking SRE score (SRHD). Pearson's product-moment correlation and linear regression were used to analyze SRE indices and RDH variables (quantity and drinks per drinking occasion). Heritability analysis was conducted using Sequential Oligogenic Linkage Analysis Routines (SOLAR) software with SRE indices as traits of interest. Results: There was a significant relationship between SRE and RDH measures. Drinks per drinking day, maximum drinks, and quantity of drinks were significantly associated with SRTT, SRHD, and SRRD (all p < 0.05). SRTT showed significant heritability (h2 = 0.67, p = 0.025), however, the SRE subindices (SRED, SRRD, SRHD) were not significantly heritable. Analysis performed in the subset consisting of only African Americans (n = 86) showed similar trends. Conclusions: LR, as measured by the SRE, is associated with RDH. The high level of heritability of the SRE total score suggests that genetics accounts for a significant proportion of the variation in the LR to alcohol in social drinkers.