Affinity of antioxidative polyphenols for lipid bilayers evaluated with a liposome system.
Affinity of antioxidative polyphenols for lipid bilayers evaluated with a liposome system.
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用脂质体系统评估抗氧化多酚对脂质双层的亲和力。
DOI：
10.1271/bbb.62.1005
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Kei Hashimoto
中科院分区：
文献类型：
--
作者：
Tsutomu Nakayama;Koji Ono;Kei Hashimoto
我们开发了一种方法来测量的抗氧化多酚和泛醌纳入脂质体的液体双层的量，以估计其对细胞膜的亲和力。结果以“亲和因子”表示，通过将掺入的化合物的量除以添加到脂质体溶液中的量来计算。结果反映了在早期哺乳动物和细菌细胞体外实验中发现的化合物生物活性的剂量依赖性。
We developed a method to measure the amounts of antioxidative polyphenols and ubiquinones incorporated into the liquid bilayers of liposomes to estimate their affinities for cell membranes. Results were expressed in terms of an "affinity factor", calculated by division of the amount of compound incorporated by the amount added to the liposomal solution. The results reflected dose-dependence of the biological activities of the compound found in earlier in vitro experiments with mammalian and bacterial cells.