GLUCOCORTICOIDS IN BLOOD-PRESSURE REGULATION
GLUCOCORTICOIDS IN BLOOD-PRESSURE REGULATION
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DOI：
10.1159/000181807
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发表时间：
1990-09-01
期刊：
影响因子：
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通讯作者：
GRUNFELD, JP
中科院分区：
文献类型：
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作者：
GRUNFELD, JP
糖皮质激素过量与人类和动物的高血压有关。这种类型的高血压发作迅速，与盐摄入量无关；它可以被糖皮质激素拮抗剂抑制，如RU486。在正常大鼠中，RU486能减弱血管对去甲肾上腺素和血管紧张素II的反应性。在低盐饮食的正常大鼠中，由于血管阻力降低，它导致血压下降约20毫米汞柱。这表明在某些情况下，内源性糖皮质激素通过增强血管反应性来维持血压。
Glucocorticoid excess is associated with hypertension in man and in animals. This type of hypertension is of rapid onset and independent of salt intake; it can be inhibited by glucocorticoid antagonists, such as RU486. In normal rats, RU486 blunts vascular reactivity to norepinephrine and angiotensin II. In normal rats on low-salt diet, it induces a fall in blood pressure of approximately 20 mm Hg, due to decreased vascular resistance. This suggests that in some conditions, endogenous glucocorticoids contribute to the maintenance of blood pressure by enhancing vascular reactivity.