Genetic Polymorphisms of Glutathione S-transferase M1 and Prostate Cancer Risk in Asians: A Meta-analysis of 18 Studies
Genetic Polymorphisms of Glutathione S-transferase M1 and Prostate Cancer Risk in Asians: A Meta-analysis of 18 Studies
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DOI：
10.7314/apjcp.2013.14.1.393
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Xie, Li-Ping
中科院分区：
文献类型：
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作者：
Hu, Zheng-Hui;Lin, Yi-Wei;Xie, Li-Ping
背景资料：许多研究调查了谷胱甘肽S-转移酶M1（GSTM 1）无效多态性与前列腺癌风险之间的关联，但由于结果不一致，GSTM 1对亚洲国家人群的影响仍不清楚。研究方法：我们检索了PubMed、Web of Science、Scopus、奥维德和CNKI数据库中有关GSTM 1无效基因型与亚洲国家人群前列腺癌风险之间关系的研究，并估计了汇总优势比（OR）和95%置信区间（95%CI）。结果如下：本荟萃分析共纳入18项病例对照研究，包括2,172例病例和3,258例对照，结果显示GSTM 1缺失基因型与亚洲国家人群前列腺癌风险增加显著相关（随机效应OR=1.74，95%CI 1.44 -2.09，P
Background: Many studies have investigated associations between the glutathione S-transferase M1 (GSTM1) null polymorphism and risk of prostate cancer, but the impact of GSTM1 in people who live in Asian countries is still unclear owing to inconsistencies across results. Methods: We searched the PubMed, Web of Science, Scopus, Ovid and CNKI databases for studies of associations between the GSTM1 null genotype and risk of prostate cancer in people who live in Asian countries, and estimated summary odds ratios (ORs) with 95% confidence intervals (95% CIs). Results: A total of 18 case-control studies with 2,172 cases and 3,258 controls were included in this meta-analysis, which showed the GSTM1 null genotype to be significantly associated with increased risk of prostate cancer in people who live in Asian countries (random-effects OR=1.74, 95% CI1.44-2.09, P