DEPRESSION AND IMMUNITY - A META-ANALYTIC REVIEW
DEPRESSION AND IMMUNITY - A META-ANALYTIC REVIEW
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DOI：
10.1037/0033-2909.113.3.472
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发表时间：
1993-05-01
影响因子：
22.4
通讯作者：
COHEN, S
中科院分区：
文献类型：
--
作者：
HERBERT, TB;COHEN, S
一项荟萃分析表明，临床抑郁症与细胞免疫的几个大变化有关。仅分析方法学上合理的研究，可靠的免疫改变包括淋巴细胞对有丝分裂原的增殖反应降低（效应大小rs = 0.24 - 0.45），自然杀伤细胞活性降低（r = 0.28），以及几种白细胞群数量的改变（rs = 0.45）。11 .77点)。老年和住院样本的免疫改变都更大。还有证据表明，抑郁情绪的强度与细胞免疫指标之间存在线性关系。提供了检测每个免疫结果的可靠效果所需的样本量估计。讨论了神经内分泌机制或健康实践如何将抑郁与免疫联系起来，并指定了更好地理解这些途径所需的设计特征。
A meta-analysis indicated that clinical depression was associated with several large alterations in cellular immunity. Analyzing only methodologically sound studies, reliable immune alterations included lowered proliferative response of lymphocytes to mitogens (effect size rs = .24-.45), lowered natural killer cell activity (r = .28), and alterations in numbers of several white blood cell populations (rs =. 11-.77). Immune alterations were greater in both older and hospitalized samples. There was also evidence of a linear relation between intensity of depressive affect and indicators of cellular immunity. Estimates of sample sizes needed to detect reliable effects for each immune outcome are provided. How neuroendocrine mechanisms or health practices might link depression to immunity is discussed, and design features needed to better understand these pathways are specified.