M1/M2 macrophage polarity in normal and complicated pregnancy.
M1/M2 macrophage polarity in normal and complicated pregnancy.
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DOI：
10.3389/fimmu.2014.00606
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发表时间：
2014
影响因子：
7.3
通讯作者：
Reyes L
中科院分区：
文献类型：
--
作者：
Brown MB;von Chamier M;Allam AB;Reyes L
组织巨噬细胞在妊娠的各个阶段都发挥着重要作用，包括胚胎着床前的子宫间质重塑(蜕膜化)、分娩和产后子宫复旧。子宫胎盘巨噬细胞的激活状态和功能在很大程度上取决于局部组织微环境。因此，巨噬细胞参与多种活动，如免疫细胞活动的调节、胎盘细胞入侵、血管生成和组织重塑。子宫微环境的破坏，特别是在妊娠早期(蜕膜化、着床和胎盘形成)，会对巨噬细胞的活动产生深远的影响，进而影响妊娠结局。在这篇综述中，我们将概述人类和啮齿动物在正常妊娠期间子宫-胎盘巨噬细胞激活的时间和空间调节，并重点介绍最近的发现。我们还将讨论宫内环境中M1/M2失调在不良妊娠结局中的作用。
Tissue macrophages play an important role in all stages of pregnancy, including uterine stromal remodeling (decidualization) before embryo implantation, parturition, and post-partum uterine involution. The activation state and function of utero-placental macrophages are largely dependent on the local tissue microenvironment. Thus, macrophages are involved in a variety of activities such as regulation of immune cell activities, placental cell invasion, angiogenesis, and tissue remodeling. Disruption of the uterine microenvironment, particularly during the early stages of pregnancy (decidualization, implantation, and placentation) can have profound effects on macrophage activity and subsequently impact pregnancy outcome. In this review, we will provide an overview of the temporal and spatial regulation of utero-placental macrophage activation during normal pregnancy in human beings and rodents with a focus on more recent findings. We will also discuss the role of M1/M2 dysregulation within the intrauterine environment during adverse pregnancy outcomes.