PASSIVE SMOKING BY HUMANS SENSITIZES CIRCULATING NEUTROPHILS
PASSIVE SMOKING BY HUMANS SENSITIZES CIRCULATING NEUTROPHILS
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DOI：
10.1164/ajrccm/144.3_pt_1.570
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发表时间：
1991-09-01
期刊：
影响因子：
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通讯作者：
VANRENSBURG, AJ
中科院分区：
文献类型：
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作者：
ANDERSON, R;THERON, AJ;VANRENSBURG, AJ
被动吸入香烟烟雾的促炎作用进行了研究，共16个健康，年轻的非吸烟者（平均年龄29 +/- 1.4岁，11名女性和5名男性）暴露于积极吸烟的个人在通风不良的房间。在暴露于香烟烟雾3小时之前和之后测量神经功能。被动吸烟与白细胞计数增加（平均增加33%，p < 0.005）、趋化性（57%，p < 0.001）和刺激中性粒细胞释放反应性氧化剂（71%，p < 0.005）相关。这些结果在第二项旨在消除连续静脉穿刺可能的并发症影响的研究中得到证实。血浆促炎细胞因子白细胞介素-1（IL-1）α、IL-1-β、IL-6和肿瘤坏死因子α（TNF-α）的浓度不受被动吸烟的影响。这些结果表明，吸入侧流烟草烟雾促进中性粒细胞的全身启动。这些潜在的促炎事件可能会诱导被动吸烟者肺部氧化剂介导的组织损伤和致癌作用。
The proinflammatory effects of passive inhalation of cigarette smoke were investigated by exposing a total of 16 healthy, young nonsmokers (mean age 29 +/- 1.4 yr, 11 women and five men) to actively smoking individuals in a poorly-ventilated room. Neutrophil functions were measured before and after 3 h of exposure to cigarette smoke. Passive cigarette smoking was associated with increased leukocyte counts (mean increase 33%, p < 0.005), chemotaxis (57%, p < 0.001), and release of reactive oxidants (71%, p < 0.005) by stimulated neutrophils. These results were confirmed in a second study designed to eliminate the possible complicating effects of serial venepuncture. Plasma concentrations of the proinflammatory cytokines interleukin-1 (IL-1)alpha, IL-1-beta, IL-6, and tumor necrosis factor alpha (TNF-alpha) were not affected by passive smoking. These results indicate that inhalation of sidestream tobacco smoke promotes systemic priming of neutrophils. These potentially proinflammatory events may induce oxidant-mediated tissue damage and carcinogenesis in the lungs of passive smokers.