Myosin motor proteins are involved in the final stages of the secretory pathways.
Myosin motor proteins are involved in the final stages of the secretory pathways.
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DOI：
10.1042/bst0391115
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发表时间：
2011-10
影响因子：
3.9
通讯作者：
Buss F
中科院分区：
文献类型：
--
作者：
Bond LM;Brandstaetter H;Sellers JR;Kendrick-Jones J;Buss F
In eukaryotes, the final steps in both the regulated and constitutive secretory pathways can be divided into four distinct stages: 1) the ‘approach’ of secretory vesicles/granules to the plasma membrane; 2) the ‘docking’ of these vesicles/granules at the membrane itself; 3) the ‘priming’ of the secretory vesicles/granules for the fusion process; and finally 4) the ‘fusion’ of vesicular/granular membranes with the plasma membrane to permit content release from the cell. Recent work indicates that nonmuscle myosin II and the unconventional myosin motor proteins in classes 1c/1e, Va, and VI are specifically involved in these final stages of secretion. In this review, we examine the roles of these myosins in these stages of the secretory pathway and the implications of their roles for an enhanced understanding of secretion in general.
